StemSynergy Therapeutics (United States)

Small-molecule inhibition of Wnt signaling through activation of casein kinase 1α

Curtis A. Thorne, Alison Hanson, Judsen Schneider et al. · Nature Chemical Biology · 2010 · 472 citations · Full text

Signal Transduction, Signaling Pathway, Molecular Pathway +11

Targeting the Wnt Pathway in Synovial Sarcoma Models

Whitney Barham, Andrea L. Frump, Taylor P. Sherrill et al. · Cancer Discovery · 2013 · 74 citations · Full text

Repurposing the FDA-Approved Pinworm Drug Pyrvinium as a Novel Chemotherapeutic Agent for Intestinal Polyposis

Bin Li, Colin A. Flaveny, Camilla Giambelli et al. · PLoS ONE · 2014 · 64 citations · Full text

Intestinal Polyposis, Chemoprevention Strategy, Gastrointestinal Pharmacology +20

The Antihelmintic Drug Pyrvinium Pamoate Targets Aggressive Breast Cancer

Wei Xu, Lara Lacerda, Bisrat G. Debeb et al. · PLoS ONE · 2013 · 49 citations · Full text

Breast Oncology, Oncology, Medicine +14

A Biochemical Screen for Identification of Small-Molecule Regulators of the Wnt Pathway Using Xenopus Egg Extracts

Curtis A. Thorne, Bonnie LaFleur, Michelle Lewis et al. · SLAS DISCOVERY · 2011 · 18 citations · Full text