Concepedia

Werner Syndrome

Werner Syndrome is a rare autosomal recessive disorder belonging to the class of human diseases characterized by premature aging and caused by mutations in the WRN gene, which encodes a DNA helicase involved in DNA repair and genomic stability.

713

Publications

47.1K

Citations

2.7K

Authors

797

Institutions

Publications per year

2017–2026

76

Variants

Adult Progeria

Parents

Publications

713

Positional Cloning of the Werner's Syndrome Gene

Chang-En Yu, Junko Oshima, Ying‐Hui Fu et al. · Science · 1996 · 1.7K citations

, , +14

mut-7 of C. elegans, Required for Transposon Silencing and RNA Interference, Is a Homolog of Werner Syndrome Helicase and RNaseD

René F. Ketting, Thomas Haverkamp, Henri G.A.M. van Luenen et al. · Cell · 1999 · 746 citations · Full text

, , +10

The Werner syndrome protein is a DNA helicase

Matthew D. Gray, Jiang-Cheng Shen, Ashwini S. Kamath‐Loeb et al. · Nature Genetics · 1997 · 612 citations

, , +5

Defective Telomere Lagging Strand Synthesis in Cells Lacking WRN Helicase Activity

Laure Crabbé, Ramiro E. Verdún, Candy Haggblom et al. · Science · 2004 · 601 citations

, , +17

A Werner syndrome stem cell model unveils heterochromatin alterations as a driver of human aging

Weiqi Zhang, Jingyi Li, Keiichiro Suzuki et al. · Science · 2015 · 546 citations · Full text

, , +16

1–5 of 713

Authors

2.7K

  1. VA
    Vilhelm A. Bohr

    National Institute on Aging, United States

    62 publications · 5.4K citations

    38

    h-index

  2. JO
    Junko Oshima

    University of Washington, United States

    51 publications · 6.6K citations

    36

    h-index

  3. GM
    George M. Martin

    University of Washington, United States

    39 publications · 6.1K citations

    32

    h-index

  4. MG
    Makoto Goto

    Otsuka (Japan), Japan

    39 publications · 2.9K citations

    26

    h-index

  5. RM
    Robert M. Brosh

    National Institute on Aging, United States

    28 publications · 2.6K citations

    24

    h-index

1–5 of 2.7K

Institutions

797

  1. University of Washington

    Seattle, United States

    56 h-index

    360 publications

    37.3K citations

  2. National Institute on Aging

    Baltimore, United States

    49 h-index

    295 publications

    31K citations

  3. National Institutes of Health

    Bethesda, United States

    46 h-index

    296 publications

    32.1K citations

  4. GeneCare Research Institute (Japan)

    Kamakura, Japan

    20 h-index

    116 publications

    8.4K citations

  5. Chiba University

    Chiba, Japan

    19 h-index

    133 publications

    3.9K citations

  6. The University of Osaka

    Osaka, Japan

    16 h-index

    92 publications

    7.3K citations

  7. Otsuka (Japan)

    Tokyo, Japan

    16 h-index

    40 publications

    4.3K citations

  8. University of Arkansas for Medical Sciences

    Little Rock, United States

    15 h-index

    65 publications

    3.6K citations

1–8 of 797

Venues

  1. Journal of Biological Chemistry

    JBC · 58 publications · 6.3K citations

    40

    h-index

  2. Nucleic Acids Research

    38 publications · 2.6K citations

    28

    h-index

  3. PubMed

    Repository · 43 publications · 2.1K citations

    24

    h-index

  4. Proceedings of the National Academy of Sciences

    PNAS · 21 publications · 3.8K citations

    20

    h-index

  5. Human Genetics

    20 publications · 1.7K citations

    18

    h-index

1–5