Volume of Distribution Differences is a pharmacokinetic parameter that quantifies the interspecies variation in the apparent volume in which a drug is distributed relative to plasma concentration, reflecting differences in tissue binding, perfusion, and physicochemical properties across species.
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Volume of Distribution in Drug Design
Dennis A. Smith, Kevin Beaumont, Tristan S. Maurer et al. · Journal of Medicinal Chemistry · 2015 · 303 citations · Full text
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