Concepedia

Viral Attenuation

Viral Attenuation is a methodological strategy in oncolytic virotherapy involving the reduction of viral pathogenicity while preserving replicative capacity and immunogenicity, typically through genetic modifications or serial passaging to enable selective tumor cell targeting.

199

Publications

11.3K

Citations

1.2K

Authors

345

Institutions

Publications per year

2017–2026

43

Parents

Publications

199

Recombinant Factor VIII for the Treatment of Previously Untreated Patients with Hemophilia A -- Safety, Efficacy, and Development of Inhibitors

Jeanne M. Lusher, Steven Arkin, Charles F. Abildgaard et al. · New England Journal of Medicine · 1993 · 494 citations · Full text

, , +14

The Genomes of Sheeppox and Goatpox Viruses

E. R. Tulman, Claudio L. Afonso, Zhiqiang Lu et al. · Journal of Virology · 2002 · 389 citations · Full text

, , +17

Transgenic mice expressing a human poliovirus receptor: A new model for poliomyelitis

Ruibao Ren, Frank Costantini, Edward J. Gorgacz et al. · Cell · 1990 · 380 citations

, , +17

Internal ribosomal entry site substitution eliminates neurovirulence in intergeneric poliovirus recombinants.

Matthias Gromeier, Louis Alexander, Eckard Wimmer · Proceedings of the National Academy of Sciences · 1996 · 330 citations

, , +17

Localized attenuation and discontinuous synthesis during vesicular stomatitis virus transcription

Linda E. Iverson, John K. Rose · Cell · 1981 · 324 citations

, , +14

1–5 of 199

Authors

1.2K

  1. AM
    Andrew Macadam

    National Institute for Biological Standards and Control, United Kingdom

    10 publications · 795 citations

    10

    h-index

  2. VR
    Vincent R. Racaniello

    Columbia University, United States

    7 publications · 1K citations

    7

    h-index

  3. PD
    P. D. Minor

    National Institute for Biological Standards and Control, United Kingdom

    5 publications · 648 citations

    5

    h-index

  4. PD
    Philip D. Minor

    National Institute for Biological Standards and Control, United Kingdom

    5 publications · 263 citations

    5

    h-index

  5. JW
    Jeffrey W. Almond

    University of Reading, United Kingdom

    5 publications · 187 citations

    5

    h-index

1–5 of 1.2K

Institutions

345

  1. National Institute for Biological Standards and Control

    Potters Bar, United Kingdom

    12 h-index

    53 publications

    3.8K citations

  2. Mayo Clinic

    Rochester, United States

    8 h-index

    27 publications

    3K citations

  3. Institut Pasteur

    Paris, France

    6 h-index

    29 publications

    1.6K citations

  4. University of Reading

    Reading, United Kingdom

    6 h-index

    23 publications

    2.1K citations

  5. Inserm

    Paris, France

    6 h-index

    26 publications

    1.1K citations

  6. Columbia University

    New York, United States

    5 h-index

    13 publications

    2.8K citations

  7. Mayo Clinic in Arizona

    Scottsdale, United States

    5 h-index

    15 publications

    885 citations

  8. Center for Biologics Evaluation and Research

    Silver Spring, United States

    5 h-index

    20 publications

    590 citations

1–8 of 345

Venues

  1. Journal of Virology

    JVI · 41 publications · 3.2K citations

    30

    h-index

  2. Virology

    11 publications · 639 citations

    10

    h-index

  3. PubMed

    Repository · 10 publications · 202 citations

    10

    h-index

  4. Journal of General Virology

    8 publications · 512 citations

    9

    h-index

  5. Proceedings of the National Academy of Sciences

    PNAS · 7 publications · 750 citations

    7

    h-index

1–5