Concepedia

Vigabatrin Therapy

Vigabatrin Therapy is a pharmacotherapeutic intervention that involves the administration of vigabatrin, an irreversible GABA transaminase inhibitor, to selectively enhance central nervous system GABAergic neurotransmission for the management of refractory pediatric epilepsy syndromes, notably infantile spasms and tuberous sclerosis complex-associated seizures.

531

Publications

26.7K

Citations

2.1K

Authors

640

Institutions

Publications per year

2017–2026

44

Parents

Publications

531

Effects of antiepileptic drugs on motor cortex excitability in humans: A transcranial magnetic stimulation study

Ulf Ziemann, S. Lönnecker, Bernhard J. Steinhoff et al. · Annals of Neurology · 1996 · 1.1K citations

, , +17

Localized 1H NMR measurements of gamma-aminobutyric acid in human brain in vivo.

Douglas L. Rothman, Ognen A. C. Petroff, Kevin L. Behar et al. · Proceedings of the National Academy of Sciences · 1993 · 519 citations

, , +13

The United Kingdom Infantile Spasms Study (UKISS) comparing hormone treatment with vigabatrin on developmental and epilepsy outcomes to age 14 months: a multicentre randomised trial

Andrew Lux, Stuart W. Edwards, Eleanor Hancock et al. · The Lancet Neurology · 2005 · 401 citations

, , +12

The United Kingdom Infantile Spasms Study comparing vigabatrin with prednisolone or tetracosactide at 14 days: a multicentre, randomised controlled trial

Andrew Lux, Stuart W. Edwards, Eleanor Hancock et al. · The Lancet · 2004 · 378 citations

, , +6

Evidence-based guideline update: Medical treatment of infantile spasms [RETIRED]

Cristina Go, Mark T. Mackay, Shelly K. Weiss et al. · Neurology · 2012 · 337 citations · Full text

, , +13

1–5 of 531

Authors

2.1K

  1. JP
    J. P. Mumford

    University of Pavia, Italy

    17 publications · 1.7K citations

    17

    h-index

  2. CC
    Catherine Chiron

    Inserm, France

    16 publications · 1.5K citations

    15

    h-index

  3. OD
    Olivier Dulac

    Inserm, France

    13 publications · 1.3K citations

    12

    h-index

  4. PR
    Paavo Riekkinen

    University of Eastern Finland, Finland

    13 publications · 420 citations

    12

    h-index

  5. JW
    Josemir W. Sander

    University College London, United Kingdom

    11 publications · 539 citations

    11

    h-index

1–5 of 2.1K

Institutions

640

  1. University College London

    London, United Kingdom

    25 h-index

    94 publications

    6K citations

  2. National Hospital for Neurology and Neurosurgery

    London, United Kingdom

    20 h-index

    59 publications

    3.2K citations

  3. Inserm

    Paris, France

    17 h-index

    80 publications

    5.7K citations

  4. Hôpital Saint-Vincent-de-Paul

    Paris, France

    16 h-index

    50 publications

    4.7K citations

  5. University of Eastern Finland

    Joensuu, Finland

    14 h-index

    62 publications

    3.1K citations

  6. Western Infirmary

    Glasgow, United Kingdom

    12 h-index

    34 publications

    1.6K citations

  7. Boston Children's Hospital

    Boston, United States

    12 h-index

    44 publications

    1.7K citations

  8. Hospital for Sick Children

    Toronto, Canada

    12 h-index

    57 publications

    2.2K citations

1–8 of 640

Venues

  1. Epilepsia

    85 publications · 4.9K citations

    43

    h-index

  2. Neurology

    29 publications · 2.6K citations

    25

    h-index

  3. Epilepsy Research

    33 publications · 1.7K citations

    22

    h-index

  4. Journal of Child Neurology

    JCN · 26 publications · 1.2K citations

    21

    h-index

  5. British Journal of Clinical Pharmacology

    BJCP · 22 publications · 1.2K citations

    19

    h-index

1–5