Concepedia

Upf2 Function

Upf2 Function is a molecular mechanism within the nonsense-mediated mRNA decay pathway that serves as a bridging factor facilitating the interaction between Upf1 and Upf3 to enable mRNA surveillance and degradation of transcripts containing premature termination codons.

35

Publications

4K

Citations

219

Authors

114

Institutions

Publications per year

2017–2026

9

Parents

Publications

35

NMD factors UPF2 and UPF3 bridge UPF1 to the exon junction complex and stimulate its RNA helicase activity

Hala Chamieh, Lionel Ballut, Fabien Bonneau et al. · Nature Structural & Molecular Biology · 2007 · 345 citations

, , +15

Molecular Mechanisms for the RNA-Dependent ATPase Activity of Upf1 and Its Regulation by Upf2

Sutapa Chakrabarti, Uma Jayachandran, Fabien Bonneau et al. · Molecular Cell · 2011 · 307 citations · Full text

, , +8

Identification of a novel component of the nonsense-mediated mRNA decay pathway by use of an interacting protein screen.

Fei He, Allan Jacobson · Genes & Development · 1995 · 287 citations · Full text

, , +13

NMD is essential for hematopoietic stem and progenitor cells and for eliminating by-products of programmed DNA rearrangements

Joachim Weischenfeldt, Inge Damgaard, David Bryder et al. · Genes & Development · 2008 · 285 citations · Full text

, , +17

Identification and characterization of genes that are required for the accelerated degradation of mRNAs containing a premature translational termination codon.

Ying Cui, K W Hagan, S Zhang et al. · Genes & Development · 1995 · 280 citations · Full text

, , +17

1–5 of 35

Authors

219

  1. BP
    Bo Porse

    University of Copenhagen, Denmark

    6 publications · 584 citations

    6

    h-index

  2. SC
    S. Cusack

    European Molecular Biology Laboratory, France

    3 publications · 427 citations

    3

    h-index

  3. YK
    Yoon Ki Kim

    Korea University, South Korea

    2 publications · 269 citations

    2

    h-index

  4. JB
    Jianqiang Bao

    University of Nevada, Reno, United States

    2 publications · 135 citations

    2

    h-index

  5. ID
    Inge Damgaard

    University of Copenhagen, Denmark

    2 publications · 360 citations

    2

    h-index

1–5 of 219

Institutions

114

  1. Centre National de la Recherche Scientifique

    Paris, France

    6 h-index

    22 publications

    3.2K citations

  2. University of Copenhagen

    Copenhagen, Denmark

    6 h-index

    20 publications

    2K citations

  3. Rigshospitalet

    Copenhagen, Denmark

    5 h-index

    14 publications

    1K citations

  4. European Molecular Biology Laboratory

    Grenoble, France

    4 h-index

    12 publications

    1.4K citations

  5. Unit of Virus Host Cell Interactions

    Grenoble, France

    3 h-index

    11 publications

    1.1K citations

  6. Howard Hughes Medical Institute

    Chevy Chase, United States

    2 h-index

    4 publications

    577 citations

  7. Max Planck Institute of Biochemistry

    Martinsried, Germany

    2 h-index

    7 publications

    1.9K citations

  8. Nanyang Technological University

    Singapore, Singapore

    2 h-index

    2 publications

    96 citations

1–8 of 114

Venues

  1. Nucleic Acids Research

    5 publications · 403 citations

    5

    h-index

  2. Genes & Development

    4 publications · 1K citations

    4

    h-index

  3. Molecular and Cellular Biology

    MCB · 3 publications · 526 citations

    3

    h-index

  4. PLoS Genetics

    2 publications · 153 citations

    2

    h-index

  5. Nature Communications

    2 publications · 83 citations

    2

    h-index

1–5