Concepedia

Upf1 Phosphorylation

Upf1 Phosphorylation is a post-translational modification in which the Upf1 protein, a central effector of the nonsense-mediated mRNA decay pathway, undergoes phosphorylation primarily at conserved serine and threonine residues by the kinase SMG1, thereby triggering mRNA degradation through the recruitment of downstream decay factors.

54

Publications

4.9K

Citations

304

Authors

138

Institutions

Publications per year

2017–2026

15

Parents

Publications

54

Binding of a novel SMG-1–Upf1–eRF1–eRF3 complex (SURF) to the exon junction complex triggers Upf1 phosphorylation and nonsense-mediated mRNA decay

Isao Kashima, Akio Yamashita, Natsuko Izumi et al. · Genes & Development · 2006 · 644 citations · Full text

, , +17

Upf1 Phosphorylation Triggers Translational Repression during Nonsense-Mediated mRNA Decay

Olaf Isken, Yoon Ki Kim, Nao Hosoda et al. · Cell · 2008 · 296 citations · Full text

, , +14

N- and C-terminal Upf1 phosphorylations create binding platforms for SMG-6 and SMG-5:SMG-7 during NMD

Yukiko Okada-Katsuhata, Akio Yamashita, Kei Kutsuzawa et al. · Nucleic Acids Research · 2011 · 260 citations · Full text

, , +17

SMG-8 and SMG-9, two novel subunits of the SMG-1 complex, regulate remodeling of the mRNA surveillance complex during nonsense-mediated mRNA decay

Akio Yamashita, Natsuko Izumi, Isao Kashima et al. · Genes & Development · 2009 · 246 citations · Full text

, , +16

SMG-2 Is a Phosphorylated Protein Required for mRNA Surveillance in <i>Caenorhabditis elegans</i> and Related to Upf1p of Yeast

Michelle F. Page, Brian Carr, Kirk R. Anders et al. · Molecular and Cellular Biology · 1999 · 226 citations · Full text

, , +17

1–5 of 54

Authors

304

  1. AY
    Akio Yamashita

    Yokohama City University, Japan

    10 publications · 1.6K citations

    10

    h-index

  2. SO
    Shigeo Ohno

    Yokohama City University, Japan

    7 publications · 1.4K citations

    7

    h-index

  3. LE
    Lynne E. Maquat

    University of Rochester, United States

    5 publications · 774 citations

    5

    h-index

  4. YK
    Yoon Ki Kim

    Korea University, South Korea

    5 publications · 553 citations

    5

    h-index

  5. NI
    Natsuko Izumi

    The University of Tokyo, Japan

    4 publications · 1.2K citations

    4

    h-index

1–5 of 304

Institutions

138

  1. Yokohama City University

    Yokohama, Japan

    10 h-index

    45 publications

    11.1K citations

  2. Centre National de la Recherche Scientifique

    Paris, France

    6 h-index

    26 publications

    1.4K citations

  3. University of Rochester

    Rochester, United States

    6 h-index

    18 publications

    2.8K citations

  4. University of Wisconsin–Madison

    Madison, United States

    4 h-index

    15 publications

    2K citations

  5. Korea University

    Seoul, South Korea

    4 h-index

    12 publications

    663 citations

  6. University of Edinburgh

    Edinburgh, United Kingdom

    3 h-index

    8 publications

    340 citations

  7. Institut de Biologie de l'École Normale Supérieure

    Paris, France

    3 h-index

    5 publications

    360 citations

  8. Institute of Genetics and Cancer

    Edinburgh, United Kingdom

    3 h-index

    7 publications

    320 citations

1–8 of 138

Venues

  1. Nucleic Acids Research

    13 publications · 1K citations

    13

    h-index

  2. Genes & Development

    6 publications · 1.3K citations

    6

    h-index

  3. Molecular and Cellular Biology

    MCB · 5 publications · 535 citations

    5

    h-index

  4. Nature Communications

    3 publications · 254 citations

    3

    h-index

  5. The Plant Journal

    3 publications · 146 citations

    3

    h-index

1–5