Concepedia

Two-component Regulatory Systems

Two-Component Regulatory Systems is a signal transduction mechanism in prokaryotes that enables bacteria to sense and respond to environmental changes through a phosphorylation-dependent interaction between a membrane-bound sensor kinase and a cognate response regulator, thereby modulating gene expression, including virulence genes, in a coordinated manner.

1.5K

Publications

109.5K

Citations

5.8K

Authors

1.3K

Institutions

Publications per year

2017–2026

275

Variants

TcsTwo-component Systems

Parents

Publications

1.5K

A two-component system that regulates an osmosensing MAP kinase cascade in yeast

Tatsuya Maeda, Susannah M. Wurgler‐Murphy, Haruo Saito · Nature · 1994 · 1.1K citations

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A two-component regulatory system (phoP phoQ) controls Salmonella typhimurium virulence.

Samuel I. Miller, A M Kukral, John J. Mekalanos · Proceedings of the National Academy of Sciences · 1989 · 934 citations · Full text

, , +17

Biological Insights from Structures of Two-Component Proteins

Rong Gao, Ann Stock · Annual Review of Microbiology · 2009 · 792 citations · Full text

, , +17

Major Structural Differences and Novel Potential Virulence Mechanisms from the Genomes of Multiple Campylobacter Species

Derrick E. Fouts, Emmanuel F. Mongodin, Robert E. Mandrell et al. · PLoS Biology · 2004 · 548 citations · Full text

, , +17

Autoinducer 2 Controls Biofilm Formation in <i>Escherichia coli</i> through a Novel Motility Quorum-Sensing Regulator (MqsR, B3022)

Andrés Fernando González Barrios, Rongjun Zuo, Yoshifumi Hashimoto et al. · Journal of Bacteriology · 2005 · 540 citations · Full text

, , +17

1–5 of 1.5K

Authors

5.8K

  1. EA
    Eduardo A. Groisman

    Howard Hughes Medical Institute, United States

    21 publications · 2.4K citations

    21

    h-index

  2. DG
    Dimitris Georgellis

    Universidad Nacional Autónoma de México, Mexico

    15 publications · 1.3K citations

    14

    h-index

  3. RE
    Robert E. W. Hancock

    University of British Columbia, Canada

    12 publications · 1.3K citations

    12

    h-index

  4. VS
    Valley Stewart

    University of California, Davis, United States

    12 publications · 687 citations

    11

    h-index

  5. EW
    Eugene W. Nester

    University of Washington, United States

    11 publications · 1.1K citations

    11

    h-index

1–5 of 5.8K

Institutions

1.3K

  1. Harvard University

    Cambridge, United States

    39 h-index

    140 publications

    23.1K citations

  2. Centre National de la Recherche Scientifique

    Paris, France

    33 h-index

    202 publications

    11.4K citations

  3. Howard Hughes Medical Institute

    Chevy Chase, United States

    28 h-index

    64 publications

    9.1K citations

  4. Institut Pasteur

    Paris, France

    28 h-index

    107 publications

    11.9K citations

  5. University of Washington

    Seattle, United States

    26 h-index

    72 publications

    9.1K citations

  6. Universidad Nacional Autónoma de México

    Mexico City, Mexico

    20 h-index

    68 publications

    3.3K citations

  7. University of British Columbia

    Vancouver, Canada

    19 h-index

    76 publications

    7.9K citations

  8. Inserm

    Paris, France

    18 h-index

    76 publications

    5.9K citations

1–8 of 1.3K

Venues

  1. Journal of Bacteriology

    JB · 365 publications · 33.3K citations

    108

    h-index

  2. Proceedings of the National Academy of Sciences

    PNAS · 72 publications · 9.3K citations

    53

    h-index

  3. Molecular Microbiology

    75 publications · 6.9K citations

    50

    h-index

  4. Infection and Immunity

    IAI · 76 publications · 5.7K citations

    47

    h-index

  5. Microbiology

    93 publications · 5.3K citations

    45

    h-index

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