Concepedia

Two-compartment Elimination

Two-Compartment Elimination is a pharmacokinetic model that describes the distribution and elimination of a substance in the body using two interconnected compartments—a central compartment representing highly perfused tissues and a peripheral compartment representing less rapidly perfused tissues—distinguished from single-compartment models by its biphasic concentration-time profile reflecting both distribution and elimination phases.

209

Publications

9.4K

Citations

1.1K

Authors

399

Institutions

Publications per year

2017–2026

36

Parents

Publications

209

In vivo administration of purified human interleukin 2. II. Half life, immunologic effects, and expansion of peripheral lymphoid cells in vivo with recombinant IL 2.

Michael T. Lotze, Yvedt L. Matory, Stephen E. Ettinghausen et al. · The Journal of Immunology · 1985 · 614 citations

, , +9

A two-compartment model of pulmonary nitric oxide exchange dynamics

Nikolaos M. Tsoukias, Steven C. George · Journal of Applied Physiology · 1998 · 471 citations

, , +17

Pharmacokinetics of cathinone, cathine and norephedrine after the chewing of khat leaves

Stefan W. Toennes, Sebastian Harder, Markus A. Schramm et al. · British Journal of Clinical Pharmacology · 2003 · 297 citations · Full text

, , +13

A dispersion model of hepatic elimination: 1. Formulation of the model and bolus considerations

Michael S. Roberts, Malcolm Rowland · Journal of Pharmacokinetics and Biopharmaceutics · 1986 · 262 citations

, , +16

Biological half-time of cadmium in the blood of workers after cessation of exposure.

Lars Järup, Artur Rogenfelt, C G Elinder et al. · Scandinavian Journal of Work Environment & Health · 1983 · 209 citations · Full text

, , +11

1–5 of 209

Authors

1.1K

  1. GP
    Gilles Paintaud

    Université de Tours, France

    4 publications · 281 citations

    4

    h-index

  2. DT
    David Ternant

    Université de Tours, France

    3 publications · 231 citations

    3

    h-index

  3. TG
    Torgny Groth

    Uppsala University, Sweden

    3 publications · 42 citations

    3

    h-index

  4. PK
    P. Koeppe

    Freie Universität Berlin, Germany

    3 publications · 79 citations

    3

    h-index

  5. GH
    Georg Hempel

    University of Münster, Germany

    3 publications · 78 citations

    3

    h-index

1–5 of 1.1K

Institutions

399

  1. Uppsala University

    Uppsala, Sweden

    5 h-index

    8 publications

    399 citations

  2. Inserm

    Paris, France

    5 h-index

    26 publications

    810 citations

  3. Université de Tours

    Tours, France

    4 h-index

    24 publications

    1.7K citations

  4. Université Paris Cité

    Paris, France

    4 h-index

    10 publications

    309 citations

  5. University of California, Davis

    Davis, United States

    4 h-index

    10 publications

    330 citations

  6. University of Alabama at Birmingham

    Birmingham, United States

    4 h-index

    24 publications

    1.3K citations

  7. The University of Queensland

    Brisbane, Australia

    4 h-index

    14 publications

    311 citations

  8. University of California, San Francisco

    San Francisco, United States

    4 h-index

    4 publications

    324 citations

1–8 of 399

Venues

  1. Antimicrobial Agents and Chemotherapy

    AAC · 29 publications · 1.3K citations

    21

    h-index

  2. PubMed

    Repository · 22 publications · 794 citations

    13

    h-index

  3. Clinical Pharmacology & Therapeutics

    CPT · 8 publications · 528 citations

    9

    h-index

  4. Journal of Antimicrobial Chemotherapy

    JAC · 7 publications · 188 citations

    7

    h-index

  5. The Journal of Clinical Pharmacology

    6 publications · 272 citations

    6

    h-index

1–5