Concepedia

Tumor-selective Activation

Tumor-Selective Activation is a biopharmaceutical strategy within prodrug design that refers to the preferential enzymatic or chemical conversion of an inactive prodrug into its active cytotoxic form specifically within tumor tissues, thereby minimizing systemic toxicity and enhancing therapeutic efficacy.

64

Publications

4.3K

Citations

451

Authors

136

Institutions

Publications per year

2017–2026

17

Parents

Publications

64

Selective activation of NF-κB subunits in human breast cancer: potential roles for NF-κB2/p52 and for Bcl-3

Patricia C. Cogswell, Denis C. Guttridge, William K. Funkhouser et al. · Oncogene · 2000 · 452 citations

, , +14

Chemically triggered drug release from an antibody-drug conjugate leads to potent antitumour activity in mice

Raffaella Rossin, Ron M. Versteegen, Jeremy Wu et al. · Nature Communications · 2018 · 277 citations · Full text

, , +17

Tumor-Specific Activation of an EGFR-Targeting Probody Enhances Therapeutic Index

Luc Desnoyers, Olga Vasiljeva, Jennifer Richardson et al. · Science Translational Medicine · 2013 · 271 citations

, , +14

Treatment of Colon and Lung Cancer Patients with<b><i>ex Vivo</i></b>Heat Shock Protein 70-Peptide-Activated, Autologous Natural Killer Cells

Stefan W. Krause, Robert Gastpar, Reinhard Andreesen et al. · Clinical Cancer Research · 2004 · 242 citations · Full text

, , +17

Elucidation of the mechanism enabling tumor selective prodrug monotherapy.

Klaus Bosslet, Rainer H. Straub, Matthias Blumrich et al. · PubMed · 1998 · 226 citations

, , +13

1–5 of 64

Authors

451

  1. LH
    Laurence H. Patterson

    University of Bradford, United Kingdom

    3 publications · 114 citations

    3

    h-index

  2. LF
    Lutz F. Tietze

    University of Göttingen, Germany

    3 publications · 129 citations

    3

    h-index

  3. SD
    Steven D. Shnyder

    University of Bradford, United Kingdom

    3 publications · 114 citations

    3

    h-index

  4. KB
    Klaus Bosslet

    Behringwerke (Germany), Germany

    3 publications · 375 citations

    3

    h-index

  5. PM
    Paul M. Loadman

    University of Bradford, United Kingdom

    3 publications · 114 citations

    3

    h-index

1–5 of 451

Institutions

136

  1. University of Bradford

    Bradford, United Kingdom

    4 h-index

    31 publications

    1.2K citations

  2. Chinese Academy of Sciences

    Beijing, China

    3 h-index

    6 publications

    224 citations

  3. University of Göttingen

    Göttingen, Germany

    3 h-index

    13 publications

    671 citations

  4. Chinese Academy of Medical Sciences & Peking Union Medical College

    Beijing, China

    2 h-index

    7 publications

    134 citations

  5. Peking University

    Beijing, China

    2 h-index

    9 publications

    783 citations

  6. Center for Life Sciences

    Beijing, China

    2 h-index

    5 publications

    367 citations

  7. Shanghai Institutes for Biological Sciences

    Shanghai, China

    2 h-index

    3 publications

    182 citations

  8. Institute of Biomedical Sciences, Academia Sinica

    Taipei, Taiwan

    2 h-index

    7 publications

    213 citations

1–8 of 136

Venues

  1. PubMed

    Repository · 9 publications · 621 citations

    9

    h-index

  2. Journal of Medicinal Chemistry

    5 publications · 326 citations

    5

    h-index

  3. Molecular Pharmaceutics

    3 publications · 93 citations

    3

    h-index

  4. Clinical Cancer Research

    3 publications · 316 citations

    3

    h-index

  5. Bioorganic & Medicinal Chemistry

    3 publications · 91 citations

    3

    h-index

1–5