Concepedia

Trigger Loop

The "Trigger Loop" is a conserved structural motif within the active site of RNA polymerase that functions as a mobile element to facilitate nucleotide selection and catalysis during transcription elongation.

74

Publications

4.1K

Citations

239

Authors

119

Institutions

Publications per year

2017–2026

20

Parents

Publications

74

Structural Basis of Transcription: Role of the Trigger Loop in Substrate Specificity and Catalysis

Dong Wang, David Bushnell, Kenneth D. Westover et al. · Cell · 2006 · 460 citations · Full text

, , +16

The RNA Polymerase II Trigger Loop Functions in Substrate Selection and Is Directly Targeted by α-Amanitin

Craig D. Kaplan, Karl-Magnus Larsson, Roger D. Kornberg · Molecular Cell · 2008 · 261 citations · Full text

, , +13

A Central Role of the RNA Polymerase Trigger Loop in Active-Site Rearrangement during Transcriptional Pausing

Innokenti Toulokhonov, Jinwei Zhang, Murali Palangat et al. · Molecular Cell · 2007 · 205 citations · Full text

, , +16

Role of the RNA polymerase trigger loop in catalysis and pausing

Jinwei Zhang, Murali Palangat, Robert Landick · Nature Structural & Molecular Biology · 2009 · 149 citations · Full text

, , +12

Trigger loop dynamics mediate the balance between the transcriptional fidelity and speed of RNA polymerase II

Matthew H. Larson, Jing Zhou, Craig D. Kaplan et al. · Proceedings of the National Academy of Sciences · 2012 · 147 citations · Full text

, , +17

1–5 of 74

Authors

239

  1. CD
    Craig D. Kaplan

    Texas A&M University, United States

    11 publications · 1.2K citations

    11

    h-index

  2. RL
    Robert Landick

    University of Wisconsin–Madison, United States

    9 publications · 739 citations

    9

    h-index

  3. ZF
    Zachary F. Burton

    Michigan State University, United States

    7 publications · 243 citations

    7

    h-index

  4. YY
    Yulia Yuzenkova

    Newcastle University, United Kingdom

    6 publications · 304 citations

    6

    h-index

  5. NZ
    Nikolay Zenkin

    Newcastle University, United Kingdom

    6 publications · 297 citations

    6

    h-index

1–5 of 239

Institutions

119

  1. University of Wisconsin–Madison

    Madison, United States

    12 h-index

    51 publications

    4.5K citations

  2. Texas A&M University

    College Station, United States

    8 h-index

    30 publications

    1.4K citations

  3. Michigan State University

    East Lansing, United States

    7 h-index

    28 publications

    851 citations

  4. Newcastle University

    Newcastle upon Tyne, United Kingdom

    7 h-index

    21 publications

    1K citations

  5. Stanford University

    Stanford, United States

    6 h-index

    19 publications

    3.8K citations

  6. Institute of Molecular Genetics

    Moscow, Russia

    6 h-index

    15 publications

    527 citations

  7. The Ohio State University

    Columbus, United States

    5 h-index

    11 publications

    348 citations

  8. New York University

    New York, United States

    4 h-index

    9 publications

    362 citations

1–8 of 119

Venues

  1. Proceedings of the National Academy of Sciences

    PNAS · 13 publications · 762 citations

    13

    h-index

  2. Nucleic Acids Research

    10 publications · 324 citations

    10

    h-index

  3. Transcription

    5 publications · 90 citations

    5

    h-index

  4. PLoS Genetics

    4 publications · 202 citations

    4

    h-index

  5. Journal of Biological Chemistry

    JBC · 4 publications · 155 citations

    4

    h-index

1–5