Concepedia

Transporter Saturation Effects

Transporter Saturation Effects is a pharmacokinetic phenomenon in which the capacity-limited transport of prodrugs via specific membrane transporters becomes maximal, leading to a nonlinear relationship between drug concentration and uptake rate due to the occupation of all available transporter binding sites.

23

Publications

1.2K

Citations

93

Authors

43

Institutions

Publications per year

2017–2026

1

Parents

Publications

23

The relationship between external glucose concentration and cAMP levels inside Escherichia coli: implications for models of phosphotransferase-mediated regulation of adenylate cyclase

Lucinda S. McRobb, Alison K. Death, Thomas Ferenci · Microbiology · 1997 · 151 citations

, , +14

Saturation kinetics applied to in vitro effects of low prostaglandin E2 and F2α concentrations on ion transport across human jejunal mucosa

Klaus Bukhave, J Rask-Madsen · Gastroenterology · 1980 · 134 citations

, , +15

Anandamide Uptake Is Consistent with Rate-limited Diffusion and Is Regulated by the Degree of Its Hydrolysis by Fatty Acid Amide Hydrolase

Martin Kaczocha, Anita Hermann, Sherrye T. Glaser et al. · Journal of Biological Chemistry · 2006 · 96 citations · Full text

, , +17

[<sup>3</sup>H]GBR‐12935 Binding to the Dopamine Transporter Is Decreased in the Caudate Nucleus in Parkinson's Disease

Aaron Janowsky, Frank J. Vocci, Paul Berger et al. · Journal of Neurochemistry · 1987 · 89 citations

, , +17

Saturation of a shared mechanism which transports L‐arginine and L‐lysine into the brain of the living rat

Guadalupe Baños, P. M. Daniel, O. E. Pratt · The Journal of Physiology · 1974 · 69 citations

, , +13

1–5 of 23

Authors

93

  1. OE
    O. E. Pratt

    Institute of Psychiatry and Neurology, Poland

    2 publications · 100 citations

    2

    h-index

  2. PM
    P. M. Daniel

    University of Oxford, United Kingdom

    2 publications · 100 citations

    2

    h-index

  3. PA
    Peter Abraham

    RTI International, United States

    1 publications · 62 citations

    1

    h-index

  4. BL
    B. L. Fanburg

    Tufts Medical Center, United States

    1 publications · 14 citations

    1

    h-index

  5. MC
    Maxime Culot

    Université d'Artois, France

    1 publications · 33 citations

    1

    h-index

1–5 of 93

Institutions

43

  1. University of Florida

    Gainesville, United States

    2 h-index

    4 publications

    74 citations

  2. University of Copenhagen

    Copenhagen, Denmark

    2 h-index

    3 publications

    364 citations

  3. University of Vienna

    Vienna, Austria

    1 h-index

    6 publications

    378 citations

  4. State University of New York

    Albany, United States

    1 h-index

    3 publications

    288 citations

  5. Kettering University

    Flint, United States

    1 h-index

    1 publications

    52 citations

  6. University of Miami

    Coral Gables, United States

    1 h-index

    2 publications

    124 citations

  7. Institute of Psychiatry and Neurology

    Warsaw, Poland

    1 h-index

    3 publications

    93 citations

  8. Novartis (Switzerland)

    Basel, Switzerland

    1 h-index

    1 publications

    26 citations

1–8 of 43

Venues

  1. Journal of Neurochemistry

    JNC · 2 publications · 111 citations

    2

    h-index

  2. Journal of Biological Chemistry

    JBC · 2 publications · 129 citations

    2

    h-index

  3. 2

    h-index

  4. Journal of Applied Physiology

    1 publications · 14 citations

    1

    h-index

  5. Synapse

    1 publications · 62 citations

    1

    h-index

1–5