Concepedia

Transporter Affinity Optimization

Transporter Affinity Optimization is a computational and experimental strategy that systematically modifies the molecular structure of prodrugs to enhance their binding specificity and functional interaction with targeted membrane transporters, thereby improving cellular uptake and bioavailability.

24

Publications

2.2K

Citations

169

Authors

51

Institutions

Publications per year

2017–2026

2

Parents

Publications

24

Primary structure and functional characterization of a high-affinity glutamate transporter

Yoshikatsu Kanai, Matthias A. Hediger · Nature · 1992 · 1.3K citations

, , +15

Synthesis and evaluation of new arylbenzo[b]thiophene and diarylthiophene derivatives as inhibitors of the NorA multidrug transporter of Staphylococcus aureus

Jérémie Fournier Dit Chabert, Béatrice Marquez, L Neville et al. · Bioorganic & Medicinal Chemistry · 2007 · 92 citations

, , +11

Design and synthesis of peptidomimetic inhibitors of HIV-1 protease and renin. Evidence for improved transport

Amos B. Smith, Ralph Hirschmann, Alexander Pasternak et al. · Journal of Medicinal Chemistry · 1994 · 85 citations · Full text

, , +10

Exploration of the Dopamine Transporter: In Vitro and In Vivo Characterization of a High-Affinity and High-Specificity Iodinated Tropane Derivative (E)-N-(3-iodoprop-2-enyl)-2β-carbomethoxy- 3β-(4′-methylphenyl)nortropane (PE2I)

Denis Guilloteau, Patrick Emond, Jean‐Louis Baulieu et al. · Nuclear Medicine and Biology · 1998 · 71 citations

, , +16

Multivalent interactions between biotin–polyrotaxane conjugates and streptavidin as a model of new targeting for transporters

Tooru Ooya, Nobuhiko Yui · Journal of Controlled Release · 2002 · 66 citations

, , +11

1–5 of 24

Authors

169

  1. PL
    Paul L. Darke

    United States Military Academy, United States

    2 publications · 147 citations

    2

    h-index

  2. AP
    Alexander Pasternak

    Merck & Co., Inc., Rahway, NJ, USA (United States), United States

    2 publications · 147 citations

    2

    h-index

  3. TH
    Thomas H. Lanthorn

    Lexicon Pharmaceuticals (United States), United States

    2 publications · 38 citations

    2

    h-index

  4. RH
    Ralph Hirschmann

    University of Pennsylvania, United States

    2 publications · 147 citations

    2

    h-index

  5. AB
    Amos B. Smith

    University of Pennsylvania, United States

    2 publications · 147 citations

    2

    h-index

1–5 of 169

Institutions

51

  1. Centre National de la Recherche Scientifique

    Paris, France

    3 h-index

    19 publications

    1K citations

  2. Lexicon Pharmaceuticals (United States)

    The Woodlands, United States

    2 h-index

    21 publications

    402 citations

  3. Inserm

    Paris, France

    2 h-index

    13 publications

    728 citations

  4. Sorbonne Université

    Paris, France

    2 h-index

    9 publications

    528 citations

  5. Harvard University

    Cambridge, United States

    2 h-index

    4 publications

    2.7K citations

  6. Inner Mongolia Medical University

    Hohhot, China

    1 h-index

    1 publications

    33 citations

  7. Université Claude Bernard Lyon 1

    Villeurbanne, France

    1 h-index

    7 publications

    644 citations

  8. Sorbonne Paris Cité

    Paris, France

    1 h-index

    3 publications

    96 citations

1–8 of 51

Venues

  1. Journal of Medicinal Chemistry

    4 publications · 208 citations

    4

    h-index

  2. Bioorganic & Medicinal Chemistry Letters

    3 publications · 61 citations

    3

    h-index

  3. European Journal of Medicinal Chemistry

    2 publications · 65 citations

    2

    h-index

  4. Bioorganic & Medicinal Chemistry

    2 publications · 120 citations

    2

    h-index

  5. Nuclear Medicine and Biology

    NMB · 1 publications · 71 citations

    1

    h-index

1–5