Concepedia

Toxicity-guided Dose Modification

Toxicity-Guided Dose Modification is a clinical dosing strategy that adjusts drug administration regimens based on observed patient toxicity levels to optimize therapeutic safety and efficacy.

52

Publications

2.8K

Citations

414

Authors

139

Institutions

Publications per year

2017–2026

9

Parents

Publications

52

Phase II study of liposomal doxorubicin in refractory ovarian cancer: antitumor activity and toxicity modification by liposomal encapsulation.

Franco M. Muggia, John D. Hainsworth, Susan Jeffers et al. · Journal of Clinical Oncology · 1997 · 657 citations

, , +17

Phase I Trials of Molecularly Targeted Agents: Should We Pay More Attention to Late Toxicities?

Sophie Postel‐Vinay, Carlos Gomez‐Roca, L Rhoda Molife et al. · Journal of Clinical Oncology · 2011 · 138 citations

, , +16

Towards new methods for the determination of dose limiting toxicities and the assessment of the recommended dose for further studies of molecularly targeted agents – Dose-Limiting Toxicity and Toxicity Assessment Recommendation Group for Early Trials of Targeted therapies, an European Organisation for Research and Treatment of Cancer-led study

Sophie Postel‐Vinay, Laurence Collette, Xavier Paolettí et al. · European Journal of Cancer · 2014 · 122 citations

, , +17

Low-Dose Monitored Mitotane Treatment Achieves the Therapeutic Range with Manageable Side Effects in Patients with Adrenocortical Cancer<sup>1</sup>

Massimo Terzolo, Anna Pia, Alfredo Berruti et al. · The Journal of Clinical Endocrinology & Metabolism · 2000 · 116 citations · Full text

, , +15

Clinical impact of pharmacokinetically-guided dose adaptation of 5-fluorouracil: results from a multicentric randomized trial in patients with locally advanced head and neck carcinomas.

R. Féty, F. Rolland, Muriel Barberi‐Heyob et al. · PubMed · 1998 · 114 citations

, , +17

1–5 of 52

Authors

414

  1. XP
    Xavier Paolettí

    Inserm, France

    4 publications · 347 citations

    4

    h-index

  2. BL
    Bruno Lacarelle

    Hôpital de la Timone, France

    3 publications · 171 citations

    3

    h-index

  3. SB
    Stan B. Kaye

    Royal Marsden NHS Foundation Trust, United Kingdom

    3 publications · 336 citations

    3

    h-index

  4. SP
    Sophie Postel‐Vinay

    Institut Gustave Roussy, France

    3 publications · 336 citations

    3

    h-index

  5. JS
    Jean‐Charles Soria

    Institut Gustave Roussy, France

    3 publications · 336 citations

    3

    h-index

1–5 of 414

Institutions

139

  1. Institut Gustave Roussy

    Villejuif, France

    4 h-index

    18 publications

    2K citations

  2. Institut Curie

    Paris, France

    4 h-index

    17 publications

    1.8K citations

  3. Inserm

    Paris, France

    4 h-index

    18 publications

    1.8K citations

  4. Royal Marsden Hospital

    London, United Kingdom

    3 h-index

    12 publications

    1.6K citations

  5. Institute of Cancer Research

    London, United Kingdom

    3 h-index

    7 publications

    240 citations

  6. European Organisation for Research and Treatment of Cancer

    Brussels, Belgium

    3 h-index

    7 publications

    605 citations

  7. Hôpital de la Timone

    Marseille, France

    3 h-index

    12 publications

    732 citations

  8. Princess Margaret Cancer Centre

    Toronto, Canada

    3 h-index

    5 publications

    237 citations

1–8 of 139

Venues

  1. Journal of Clinical Oncology

    7 publications · 982 citations

    7

    h-index

  2. Cancer Chemotherapy and Pharmacology

    4 publications · 126 citations

    4

    h-index

  3. PubMed

    Repository · 4 publications · 277 citations

    4

    h-index

  4. European Journal of Cancer

    3 publications · 208 citations

    3

    h-index

  5. Blood

    2 publications · 155 citations

    2

    h-index

1–5