Concepedia

Top-down Proteomics Workflows

Top-Down Proteomics Workflows is a systematic analytical framework in proteomics that characterizes intact proteins directly without prior enzymatic digestion, distinguishing it from bottom-up approaches by preserving and analyzing whole protein molecular species to enable comprehensive identification and quantification of proteoforms.

414

Publications

26K

Citations

1.9K

Authors

572

Institutions

Publications per year

2017–2026

186

Parents

Publications

414

A generic protein purification method for protein complex characterization and proteome exploration

Guillaume Rigaut, Anna Shevchenko, Berthold Rutz et al. · Nature Biotechnology · 1999 · 2.7K citations

, , +16

Mapping intact protein isoforms in discovery mode using top-down proteomics

John C. Tran, Leonid Zamdborg, Dorothy R. Ahlf et al. · Nature · 2011 · 658 citations · Full text

, , +13

Peer Reviewed: Top-Down Proteomics

Neil L. Kelleher · Analytical Chemistry · 2004 · 496 citations

, , +16

High-throughput proteomics: a methodological mini-review

Miao Cui, Chao Cheng, Lanjing Zhang · Laboratory Investigation · 2022 · 361 citations · Full text

, , +14

The Human Proteome Project: Current State and Future Direction

Pierre Legrain, Ruedi Aebersold, Alexander I. Archakov et al. · Molecular & Cellular Proteomics · 2011 · 356 citations · Full text

, , +17

1–5 of 414

Authors

1.9K

  1. NL
    Neil L. Kelleher

    Northwestern University, United States

    46 publications · 4.6K citations

    36

    h-index

  2. YG
    Ying Ge

    University of Wisconsin–Madison, United States

    28 publications · 1.9K citations

    23

    h-index

  3. PM
    Paul M. Thomas

    Northwestern University, United States

    24 publications · 2.6K citations

    22

    h-index

  4. RT
    Ryan T. Fellers

    Northwestern University, United States

    21 publications · 1.4K citations

    20

    h-index

  5. LS
    Liangliang Sun

    Michigan State University, United States

    20 publications · 735 citations

    17

    h-index

1–5 of 1.9K

Institutions

572

  1. Northwestern University

    Evanston, United States

    31 h-index

    241 publications

    23.3K citations

  2. University of Wisconsin–Madison

    Madison, United States

    28 h-index

    285 publications

    18.2K citations

  3. Pacific Northwest National Laboratory

    Richland, United States

    17 h-index

    111 publications

    8.9K citations

  4. Indiana University – Purdue University Indianapolis

    Indianapolis, United States

    15 h-index

    31 publications

    2.2K citations

  5. Michigan State University

    East Lansing, United States

    15 h-index

    78 publications

    2.7K citations

  6. Environmental Molecular Sciences Laboratory

    Richland, United States

    13 h-index

    51 publications

    3.8K citations

  7. Centre National de la Recherche Scientifique

    Paris, France

    12 h-index

    49 publications

    1.7K citations

  8. University of Illinois Urbana-Champaign

    Urbana, United States

    11 h-index

    92 publications

    17.5K citations

1–8 of 572

Venues

  1. Analytical Chemistry

    63 publications · 4.3K citations

    39

    h-index

  2. Journal of Proteome Research

    JPR · 64 publications · 3K citations

    31

    h-index

  3. Molecular & Cellular Proteomics

    MCP · 24 publications · 2.1K citations

    21

    h-index

  4. Journal of the American Society for Mass Spectrometry

    JASMS · 21 publications · 987 citations

    19

    h-index

  5. PROTEOMICS

    23 publications · 855 citations

    18

    h-index

1–5