Concepedia

Toggle Switch Design

Toggle Switch Design is a synthetic biological framework that enables controlled, bistable gene expression states through mutual repression or activation circuits, distinguishing it from other regulatory network architectures by its capacity for stable, switch-like transitions between distinct cellular phenotypes.

37

Publications

6.6K

Citations

155

Authors

60

Institutions

Publications per year

2017–2026

17

Parents

Publications

37

Construction of a genetic toggle switch in Escherichia coli

Timothy S. Gardner, Charles R. Cantor, James J. Collins · Nature · 2000 · 4.4K citations

, , +13

Development of Genetic Circuitry Exhibiting Toggle Switch or Oscillatory Behavior in Escherichia coli

Mariette R. Atkinson, Michael A. Savageau, Jesse T. Myers et al. · Cell · 2003 · 745 citations · Full text

, , +16

Metabolic flux redirection from a central metabolic pathway toward a synthetic pathway using a metabolic toggle switch

Yuki Soma, Keigo Tsuruno, Masaru Wada et al. · Metabolic Engineering · 2014 · 199 citations

, , +15

Membrane identity and GTPase cascades regulated by toggle and cut‐out switches

Perla Del Conte‐Zerial, Lutz Brusch, Jochen C. Rink et al. · Molecular Systems Biology · 2008 · 133 citations · Full text

, , +17

Engineering longevity—design of a synthetic gene oscillator to slow cellular aging

Zhen Zhou, Yuting Liu, Yushen Feng et al. · Science · 2023 · 93 citations · Full text

, , +17

1–5 of 37

Authors

155

  1. TH
    Taizo Hanai

    Kyushu University, Japan

    3 publications · 258 citations

    3

    h-index

  2. AJ
    Alexander J. Ninfa

    University of Michigan, United States

    2 publications · 756 citations

    2

    h-index

  3. KT
    Keigo Tsuruno

    Kyushu University, Japan

    2 publications · 235 citations

    2

    h-index

  4. YS
    Yuki Soma

    Kyushu University, Japan

    2 publications · 222 citations

    2

    h-index

  5. JH
    Jeff Hasty

    University of California San Diego, United States

    2 publications · 112 citations

    2

    h-index

1–5 of 155

Institutions

60

  1. Kyushu University

    Fukuoka, Japan

    3 h-index

    13 publications

    866 citations

  2. University of Naples Federico II

    Naples, Italy

    2 h-index

    6 publications

    141 citations

  3. Japan Science and Technology Agency

    Tokyo, Japan

    2 h-index

    2 publications

    97 citations

  4. The University of Tokyo

    Tokyo, Japan

    2 h-index

    4 publications

    209 citations

  5. University of Toronto

    Toronto, Canada

    2 h-index

    7 publications

    273 citations

  6. University of Michigan

    Ann Arbor, United States

    2 h-index

    6 publications

    3K citations

  7. The University of Texas at Dallas

    Richardson, United States

    1 h-index

    3 publications

    126 citations

  8. University of California San Diego

    San Diego, United States

    1 h-index

    8 publications

    744 citations

1–8 of 60

Venues

  1. ACS Synthetic Biology

    5 publications · 210 citations

    5

    h-index

  2. Journal of The Royal Society Interface

    2 publications · 40 citations

    2

    h-index

  3. Microbial Cell Factories

    2 publications · 66 citations

    2

    h-index

  4. Nature Communications

    2 publications · 86 citations

    2

    h-index

  5. Science

    2 publications · 130 citations

    2

    h-index

1–5