Concepedia

Tissue-specific Activation

Tissue-Specific Activation is a bioprecursor prodrug strategy that belongs to the class of site-selective drug delivery mechanisms, distinguished by its reliance on enzymatic or physiological conditions unique to particular tissues to selectively convert an inactive prodrug into its active pharmacological form.

102

Publications

9.8K

Citations

559

Authors

202

Institutions

Publications per year

2017–2026

19

Variants

Tissue-selective Activation

Parents

Publications

102

Extensive and specific responses of a eukaryote to bacterial quorum-sensing signals

Ulrike Mathesius, Susan Mulders, Mengsheng Gao et al. · Proceedings of the National Academy of Sciences · 2003 · 528 citations · Full text

, , +17

Sequence requirements for myosin gene expression and regulation in Caenorhabditis elegans.

Peter G. Okkema, Susan White Harrison, V Plunger et al. · Genetics · 1993 · 438 citations · Full text

, , +14

Differential combinatorial interactions of cis-acting elements recognized by R2R3-MYB, BZIP, and BHLH factors control light-responsive and tissue-specific activation of phenylpropanoid biosynthesis genes

Ulrike Hartmann, Martin Sagasser, Mehrtens Frank et al. · Plant Molecular Biology · 2005 · 438 citations · Full text

, , +15

A thymus-specific member of the HMG protein family regulates the human T cell receptor C alpha enhancer.

Marian L. Waterman, Wolfgang Fischer, Katherine A. Jones · Genes & Development · 1991 · 367 citations · Full text

, , +15

Amphetamine and cocaine induce drug-specific activation of the c-fos gene in striosome-matrix compartment and limbic subdivisions of the striatum

Sl Harris · Proc Natl Acad Sci USA · 1990 · 354 citations

, , +17

1–5 of 102

Authors

559

  1. ÀP
    Àngel Pellicer

    New York University, United States

    2 publications · 267 citations

    2

    h-index

  2. AC
    Allan C. Spradling

    Carnegie Institution for Science, United States

    2 publications · 113 citations

    2

    h-index

  3. TL
    Thomas Lattmann

    University Hospital of Zurich, Switzerland

    2 publications · 176 citations

    2

    h-index

  4. TL
    Terry L. Orr‐Weaver

    Whitehead Institute for Biomedical Research, United States

    2 publications · 113 citations

    2

    h-index

  5. FZ
    F Zajdela

    Institut Curie, France

    2 publications · 31 citations

    2

    h-index

1–5 of 559

Institutions

202

  1. Harvard University

    Cambridge, United States

    4 h-index

    7 publications

    506 citations

  2. University Hospital Heidelberg

    Heidelberg, Germany

    3 h-index

    10 publications

    540 citations

  3. Inserm

    Paris, France

    3 h-index

    8 publications

    763 citations

  4. Heidelberg University

    Heidelberg, Germany

    3 h-index

    11 publications

    607 citations

  5. Howard Hughes Medical Institute

    Chevy Chase, United States

    3 h-index

    8 publications

    787 citations

  6. Medizinische Hochschule Hannover

    Hanover, Germany

    3 h-index

    4 publications

    570 citations

  7. Brookhaven National Laboratory

    Upton, United States

    2 h-index

    4 publications

    124 citations

  8. Michigan Medicine

    Ann Arbor, United States

    2 h-index

    4 publications

    76 citations

1–8 of 202

Venues

  1. Molecular and Cellular Biology

    MCB · 8 publications · 1K citations

    8

    h-index

  2. Journal of Biological Chemistry

    JBC · 7 publications · 749 citations

    7

    h-index

  3. PubMed

    Repository · 6 publications · 150 citations

    6

    h-index

  4. Genes & Development

    5 publications · 1.1K citations

    5

    h-index

  5. Physics in Medicine and Biology

    4 publications · 176 citations

    4

    h-index

1–5