Concepedia

Tissue Binding Effects

Tissue Binding Effects is a pharmacokinetic phenomenon characterized by the differential partitioning of a compound between blood and tissue compartments due to nonspecific binding, which modulates the apparent volume of distribution and affects the estimation of intrinsic metabolic clearance in physiologically-based pharmacokinetic models.

141

Publications

6.7K

Citations

463

Authors

147

Institutions

Publications per year

2017–2026

5

Parents

Publications

141

Tissue fractionation studies. 4. Comparative study of the binding of acid phosphatase, β-glucuronidase and cathepsin by rat-liver particles

R. Gianetto, C. De Duve · Biochemical Journal · 1955 · 885 citations · Full text

, , +9

Arterial Paclitaxel Distribution and Deposition

Christopher J. Creel, Mark A. Lovich, Elazer R. Edelman · Circulation Research · 2000 · 275 citations

, , +13

Effect of Altered Plasma Protein Binding on Apparent Volume of Distribution

Svein Øie, Thomas N. Tozer · Journal of Pharmaceutical Sciences · 1979 · 255 citations

, , +13

Disposition of chloroquine in man after single intravenous and oral doses.

O Walker, Gunnar Alván, B Beermann et al. · British Journal of Clinical Pharmacology · 1983 · 248 citations · Full text

, , +11

Tissue fractionation studies. 3. Further observations on the binding of acid phosphatase by rat-liver particles

Françoise Appelmans, C. De Duve · Biochemical Journal · 1955 · 178 citations · Full text

, , +7

1–5 of 141

Authors

463

  1. YS
    Yuichi Sugiyama

    The University of Tokyo, Japan

    4 publications · 170 citations

    4

    h-index

  2. SE
    S. E. Mills

    Purdue University West Lafayette, United States

    2 publications · 43 citations

    2

    h-index

  3. MH
    Manabu Hanano

    The University of Tokyo, Japan

    2 publications · 73 citations

    2

    h-index

  4. TI
    Tatsuji Iga

    The University of Tokyo, Japan

    2 publications · 73 citations

    2

    h-index

  5. MA
    Mark A. Goldberg

    Harvard University, United States

    2 publications · 43 citations

    2

    h-index

1–5 of 463

Institutions

147

  1. University at Buffalo, State University of New York

    Buffalo, United States

    4 h-index

    8 publications

    464 citations

  2. The University of Tokyo

    Tokyo, Japan

    3 h-index

    12 publications

    417 citations

  3. Harvard University

    Cambridge, United States

    3 h-index

    7 publications

    136 citations

  4. National Institutes of Health

    Bethesda, United States

    3 h-index

    13 publications

    246 citations

  5. Purdue University West Lafayette

    West Lafayette, United States

    3 h-index

    6 publications

    117 citations

  6. University of Glasgow

    Glasgow, United Kingdom

    2 h-index

    2 publications

    50 citations

  7. University of Bern

    Bern, Switzerland

    2 h-index

    4 publications

    234 citations

  8. University of Colorado Denver

    Denver, United States

    2 h-index

    15 publications

    253 citations

1–8 of 147

Venues

  1. PubMed

    Repository · 10 publications · 371 citations

    10

    h-index

  2. 10

    h-index

  3. Journal of Pharmacy and Pharmacology

    JPP · 6 publications · 183 citations

    6

    h-index

  4. British Journal of Pharmacology

    BJP · 5 publications · 118 citations

    5

    h-index

  5. Drug Metabolism and Disposition

    5 publications · 120 citations

    5

    h-index

1–5