Concepedia

Tfiis-mediated Transcript Cleavage

TFIIS-Mediated Transcript Cleavage is a molecular mechanism in transcription elongation whereby the transcription factor TFIIS stimulates the intrinsic nuclease activity of RNA polymerase II to cleave the 3′-end of the nascent RNA transcript, facilitating transcriptional restart from the resulting new RNA terminus following polymerase backtracking.

63

Publications

6.4K

Citations

259

Authors

97

Institutions

Publications per year

2017–2026

5

Variants

Tfiis-dependent Transcript Cleavage

Parents

Publications

63

The Cockayne syndrome group A gene encodes a WD repeat protein that interacts with CSB protein and a subunit of RNA polymerase II TFIIH

Karla A. Henning, Lei Li, Narayan V. Iyer et al. · Cell · 1995 · 505 citations · Full text

, , +15

Relationship of CDK-activating kinase and RNA polymerase II CTD kinase TFIIH/TFIIK

William J. Feaver, Jesper Q. Svejstrup, N. Lynn Henry et al. · Cell · 1994 · 426 citations

, , +12

Transcript cleavage by RNA polymerase II arrested by a cyclobutane pyrimidine dimer in the DNA template.

Brian A. Donahue, Shizhuo Yin, John‐Stephen Taylor et al. · Proceedings of the National Academy of Sciences · 1994 · 360 citations

, , +17

Architecture of the RNA Polymerase II-TFIIS Complex and Implications for mRNA Cleavage

Hubert Kettenberger, Karim‐Jean Armache, Patrick Cramer · Cell · 2003 · 356 citations · Full text

, , +14

Highly conserved core domain and unique N terminus with presumptive regulatory motifs in a human TATA factor (TFIID)

Alexander Hoffmann, Eric Sinn, Tohru Yamamoto et al. · Nature · 1990 · 344 citations

, , +16

1–5 of 63

Authors

259

  1. RG
    Robert G. Roeder

    Rockefeller University, United States

    4 publications · 785 citations

    4

    h-index

  2. JQ
    Jesper Q. Svejstrup

    Cancer Research UK, United Kingdom

    3 publications · 657 citations

    3

    h-index

  3. HG
    Hendrik G. Stunnenberg

    Radboud University Nijmegen, Netherlands

    3 publications · 144 citations

    3

    h-index

  4. DJ
    Dimitra J. Mitsiou

    National Hellenic Research Foundation, Greece

    3 publications · 144 citations

    3

    h-index

  5. SS
    Satoru Sasagawa

    Osaka International Cancer Institute, Japan

    2 publications · 59 citations

    2

    h-index

1–5 of 259

Institutions

97

  1. Rockefeller University

    New York, United States

    5 h-index

    20 publications

    4.2K citations

  2. Stanford University

    Stanford, United States

    4 h-index

    18 publications

    5K citations

  3. University of California, Berkeley

    Berkeley, United States

    4 h-index

    7 publications

    612 citations

  4. Howard Hughes Medical Institute

    Chevy Chase, United States

    3 h-index

    10 publications

    899 citations

  5. University of Chicago

    Chicago, United States

    3 h-index

    12 publications

    873 citations

  6. Memorial Sloan Kettering Cancer Center

    New York, United States

    3 h-index

    10 publications

    286 citations

  7. Harvard University

    Cambridge, United States

    3 h-index

    6 publications

    383 citations

  8. Massachusetts Institute of Technology

    Cambridge, United States

    3 h-index

    7 publications

    952 citations

1–8 of 97

Venues

  1. Journal of Biological Chemistry

    JBC · 8 publications · 366 citations

    8

    h-index

  2. Proceedings of the National Academy of Sciences

    PNAS · 7 publications · 773 citations

    7

    h-index

  3. Cell

    7 publications · 2K citations

    7

    h-index

  4. Molecular Cell

    6 publications · 609 citations

    6

    h-index

  5. Molecular and Cellular Biology

    MCB · 5 publications · 279 citations

    5

    h-index

1–5