Concepedia

Telomere Instability

Telomere Instability is a molecular phenomenon characterized by the pathological dysfunction and structural perturbation of telomeric repeats, leading to chromosomal aberrations, end-to-end fusions, and genomic instability that drive oncogenic progression.

535

Publications

44.7K

Citations

4.5K

Authors

1.2K

Institutions

Publications per year

2017–2026

105

Variants

Telomeric Instability

Parents

Publications

535

DNA Damage Foci at Dysfunctional Telomeres

Hiroyuki Takai, Agata Smogorzewska, Titia de Lange · Current Biology · 2003 · 1.4K citations · Full text

, , +14

Chromothripsis and Kataegis Induced by Telomere Crisis

John Maciejowski, Yilong Li, Nazario Bosco et al. · Cell · 2015 · 684 citations · Full text

, , +13

Loss of ATRX, Genome Instability, and an Altered DNA Damage Response Are Hallmarks of the Alternative Lengthening of Telomeres Pathway

Courtney A. Lovejoy, Wen‐Di Li, Steven Reisenweber et al. · PLoS Genetics · 2012 · 638 citations · Full text

, , +17

In vivo alteration of telomere sequences and senescence caused by mutated Tetrahymena telomerase RNAs

Guo-Liang Yu, John Bradley, Laura D. Attardi et al. · Nature · 1990 · 638 citations

, , +13

Defective Telomere Lagging Strand Synthesis in Cells Lacking WRN Helicase Activity

Laure Crabbé, Ramiro E. Verdún, Candy Haggblom et al. · Science · 2004 · 601 citations

, , +17

1–5 of 535

Authors

4.5K

  1. MA
    Marı́a A. Blasco

    Spanish National Cancer Research Centre, Spain

    13 publications · 2K citations

    13

    h-index

  2. DM
    Duncan M. Baird

    Cardiff University, United Kingdom

    13 publications · 1.8K citations

    12

    h-index

  3. TD
    Titia de Lange

    Rockefeller University, United States

    10 publications · 3.7K citations

    10

    h-index

  4. JP
    John P. Murnane

    University of California, San Francisco, United States

    10 publications · 770 citations

    10

    h-index

  5. RT
    Rodrigo T. Calado

    Universidade de São Paulo, Brazil

    10 publications · 502 citations

    10

    h-index

1–5 of 4.5K

Institutions

1.2K

  1. Inserm

    Paris, France

    20 h-index

    107 publications

    6.5K citations

  2. Harvard University

    Cambridge, United States

    20 h-index

    131 publications

    19.6K citations

  3. National Institutes of Health

    Bethesda, United States

    20 h-index

    167 publications

    17.5K citations

  4. Johns Hopkins University

    Baltimore, United States

    16 h-index

    67 publications

    10.2K citations

  5. University of California, San Francisco

    San Francisco, United States

    16 h-index

    55 publications

    5.5K citations

  6. Spanish National Cancer Research Centre

    Madrid, Spain

    15 h-index

    68 publications

    9K citations

  7. Centre National de la Recherche Scientifique

    Paris, France

    15 h-index

    50 publications

    3.6K citations

  8. The University of Texas MD Anderson Cancer Center

    Houston, United States

    15 h-index

    146 publications

    22K citations

1–8 of 1.2K

Venues

  1. Nucleic Acids Research

    23 publications · 1.2K citations

    20

    h-index

  2. Nature Communications

    20 publications · 2.3K citations

    20

    h-index

  3. Blood

    20 publications · 2.7K citations

    18

    h-index

  4. Molecular and Cellular Biology

    MCB · 18 publications · 2K citations

    17

    h-index

  5. Oncogene

    14 publications · 1K citations

    14

    h-index

1–5