Concepedia

Telomere End Replication Problem

The "Telomere End Replication Problem" is a molecular genetics phenomenon in which the inability of DNA polymerase to fully replicate the ends of linear chromosomes results in progressive shortening of telomeric DNA with each cell division.

45

Publications

4.4K

Citations

204

Authors

97

Institutions

Publications per year

2017–2026

12

Variants

End Replication Problem

Parents

Publications

45

Telomere end-replication problem and cell aging

Michael Z. Levy, Richard Allsopp, A. B. Futcher et al. · Journal of Molecular Biology · 1992 · 1.1K citations

, , +12

Telomerase Activity in Human Breast Tumors

Eiso Hiyama, Lauren Gollahon, Tsuyoshi Kataoka et al. · JNCI Journal of the National Cancer Institute · 1996 · 437 citations · Full text

, , +17

Telomerase and DNA End Replication: No Longer a Lagging Strand Problem?

Joachim Lingner, Julia Promisel Cooper, Thomas R. Cech · Science · 1995 · 393 citations · Full text

, , +9

Variability at the Telomeres of the Human X/Y Pseudoautosomal Region

Howard J. Cooke, Barbara A. Smith · Cold Spring Harbor Symposia on Quantitative Biology · 1986 · 229 citations

, , +14

Frequent recombination in telomeric DNA may extend the proliferative life of telomerase-negative cells

Susan M. Bailey · Nucleic Acids Research · 2004 · 213 citations · Full text

, , +17

1–5 of 45

Authors

204

  1. JW
    Jerry W. Shay

    The University of Texas Southwestern Medical Center, United States

    3 publications · 573 citations

    3

    h-index

  2. EH
    Eiso Hiyama

    Hiroshima University, Japan

    3 publications · 684 citations

    3

    h-index

  3. KH
    Keiko Hiyama

    Hiroshima University, Japan

    3 publications · 684 citations

    3

    h-index

  4. CW
    Carol W. Greider

    Johns Hopkins University, United States

    2 publications · 1.2K citations

    2

    h-index

  5. İM
    İlgen Mender

    The University of Texas Southwestern Medical Center, United States

    2 publications · 136 citations

    2

    h-index

1–5 of 204

Institutions

97

  1. University of Southern Denmark

    Odense, Denmark

    3 h-index

    10 publications

    870 citations

  2. The University of Texas Southwestern Medical Center

    Dallas, United States

    3 h-index

    8 publications

    2.8K citations

  3. Vejle Sygehus

    Vejle, Denmark

    3 h-index

    5 publications

    525 citations

  4. Hiroshima University

    Hiroshima, Japan

    3 h-index

    17 publications

    2.9K citations

  5. King Abdulaziz University

    Jeddah, Saudi Arabia

    2 h-index

    2 publications

    136 citations

  6. Cornell University

    Ithaca, United States

    2 h-index

    5 publications

    151 citations

  7. The University of Sydney

    Sydney, Australia

    2 h-index

    4 publications

    86 citations

  8. Technische Universität Dresden

    Dresden, Germany

    2 h-index

    7 publications

    169 citations

1–8 of 97

Venues

  1. Nucleic Acids Research

    6 publications · 377 citations

    6

    h-index

  2. BIO-PROTOCOL

    2 publications · 136 citations

    2

    h-index

  3. International Journal of Oncology

    2 publications · 247 citations

    2

    h-index

  4. Molecular and Cellular Biology

    MCB · 2 publications · 151 citations

    2

    h-index

  5. Twin Research and Human Genetics

    2 publications · 156 citations

    2

    h-index

1–5