Concepedia

Tapasin Function

Tapasin Function is a molecular chaperone mechanism within the antigen presentation pathway that specifically stabilizes and optimizes peptide loading onto MHC class I molecules through the peptide-loading complex.

154

Publications

11.4K

Citations

610

Authors

237

Institutions

Publications per year

2017–2026

18

Parents

Publications

154

Roles for Calreticulin and a Novel Glycoprotein, Tapasin, in the Interaction of MHC Class I Molecules with TAP

Bhanu Sadasivan, Bodo Ortmann, Thomas A. Spies et al. · Immunity · 1996 · 695 citations · Full text

, , +17

A Critical Role for Tapasin in the Assembly and Function of Multimeric MHC Class I-TAP Complexes

Bodo Ortmann, James Copeman, Paul J. Lehner et al. · Science · 1997 · 522 citations

, , +16

Optimization of the MHC Class I Peptide Cargo Is Dependent on Tapasin

Anthony P. Williams, Chen Au Peh, Anthony W. Purcell et al. · Immunity · 2002 · 350 citations · Full text

, , +12

Soluble Tapasin Restores MHC Class I Expression and Function in the Tapasin-Negative Cell Line .220

Michael J. Surman, Peter Cresswell · Immunity · 1998 · 292 citations · Full text

, , +17

Insights into MHC Class I Peptide Loading from the Structure of the Tapasin-ERp57 Thiol Oxidoreductase Heterodimer

Gang Dong, Pamela A. Wearsch, David R. Peaper et al. · Immunity · 2009 · 291 citations · Full text

, , +13

1–5 of 154

Authors

610

  1. PC
    Peter Cresswell

    Yale University, United States

    13 publications · 1.8K citations

    13

    h-index

  2. TE
    Tim Elliott

    University of Southampton, United Kingdom

    14 publications · 1.2K citations

    13

    h-index

  3. JC
    Joyce C. Solheim

    University of Nebraska Medical Center, United States

    11 publications · 523 citations

    11

    h-index

  4. RT
    Robert Tampé

    Goethe University Frankfurt, Germany

    9 publications · 969 citations

    9

    h-index

  5. LH
    Louise H. Boyle

    University of Cambridge, United Kingdom

    8 publications · 538 citations

    8

    h-index

1–5 of 610

Institutions

237

  1. Howard Hughes Medical Institute

    Chevy Chase, United States

    20 h-index

    53 publications

    13.4K citations

  2. Yale University

    New Haven, United States

    18 h-index

    45 publications

    8.1K citations

  3. University of Cambridge

    Cambridge, United Kingdom

    14 h-index

    36 publications

    2.5K citations

  4. University of Southampton

    Southampton, United Kingdom

    12 h-index

    40 publications

    2.6K citations

  5. Washington University in St. Louis

    St Louis, United States

    10 h-index

    33 publications

    1.9K citations

  6. Lund University

    Lund, Sweden

    9 h-index

    31 publications

    1.6K citations

  7. University of Nebraska Medical Center

    Omaha, United States

    8 h-index

    38 publications

    1K citations

  8. Vanderbilt University

    Nashville, United States

    8 h-index

    13 publications

    840 citations

1–8 of 237

Venues

  1. The Journal of Immunology

    JI · 34 publications · 2K citations

    26

    h-index

  2. European Journal of Immunology

    EJI · 14 publications · 734 citations

    13

    h-index

  3. Journal of Biological Chemistry

    JBC · 13 publications · 595 citations

    13

    h-index

  4. Proceedings of the National Academy of Sciences

    PNAS · 9 publications · 860 citations

    9

    h-index

  5. Immunity

    7 publications · 2.2K citations

    7

    h-index

1–5