Concepedia

Talin-mediated Activation

Talin-Mediated Activation is a molecular mechanism in integrin signaling wherein the cytoskeletal protein talin binds to the cytoplasmic tail of integrin subunits, inducing a conformational change that shifts integrins from a low- to high-affinity state for extracellular ligands, thereby enabling cell-matrix adhesion and downstream signal transduction.

167

Publications

18.3K

Citations

731

Authors

240

Institutions

Publications per year

2017–2026

40

Parents

Publications

167

Interaction of plasma membrane fibronectin receptor with talin—a transmembrane linkage

Alan F. Horwitz, K Duggan, Clayton A. Buck et al. · Nature · 1986 · 1.2K citations · Full text

, , +14

Talin Binding to Integrin ß Tails: A Final Common Step in Integrin Activation

Seiji Tadokoro, Sanford J. Shattil, Koji Eto et al. · Science · 2003 · 1.2K citations

, , +16

The Talin Head Domain Binds to Integrin β Subunit Cytoplasmic Tails and Regulates Integrin Activation

David Calderwood, Roy Zent, Richard P. Grant et al. · Journal of Biological Chemistry · 1999 · 719 citations · Full text

, , +17

Structural Basis of Integrin Activation by Talin

Kate L. Wegener, Anthony W. Partridge, Jaewon Han et al. · Cell · 2007 · 667 citations · Full text

, , +14

Structural Determinants of Integrin Recognition by Talin

Begoña García‐Álvarez, José M. de Pereda, David Calderwood et al. · Molecular Cell · 2003 · 520 citations · Full text

, , +14

1–5 of 167

Authors

731

  1. MH
    Mark H. Ginsberg

    University of California San Diego, United States

    22 publications · 4.8K citations

    21

    h-index

  2. DR
    David R. Critchley

    University of Leicester, United Kingdom

    22 publications · 3.4K citations

    20

    h-index

  3. DC
    David Calderwood

    Yale University, United States

    12 publications · 3.7K citations

    12

    h-index

  4. ID
    Iain D. Campbell

    University of Oxford, United Kingdom

    11 publications · 1.9K citations

    11

    h-index

  5. JQ
    Jun Qin

    Cleveland Clinic, United States

    11 publications · 1.4K citations

    11

    h-index

1–5 of 731

Institutions

240

  1. University of California San Diego

    San Diego, United States

    23 h-index

    108 publications

    11.3K citations

  2. University of Leicester

    Leicester, United Kingdom

    22 h-index

    93 publications

    12.8K citations

  3. University of Oxford

    Oxford, United Kingdom

    11 h-index

    34 publications

    4.8K citations

  4. Yale University

    New Haven, United States

    11 h-index

    29 publications

    3.8K citations

  5. Max Planck Institute of Biochemistry

    Martinsried, Germany

    10 h-index

    37 publications

    8.2K citations

  6. University of Liverpool

    Liverpool, United Kingdom

    7 h-index

    12 publications

    1.7K citations

  7. Cleveland Clinic Lerner College of Medicine

    Cleveland, United States

    7 h-index

    36 publications

    4.5K citations

  8. Scripps Research Institute

    San Diego, United States

    7 h-index

    26 publications

    13.4K citations

1–8 of 240

Venues

  1. Journal of Biological Chemistry

    JBC · 21 publications · 3.1K citations

    18

    h-index

  2. The Journal of Cell Biology

    JCB · 12 publications · 1.6K citations

    12

    h-index

  3. Journal of Cell Science

    8 publications · 390 citations

    8

    h-index

  4. Blood

    8 publications · 769 citations

    8

    h-index

  5. Proceedings of the National Academy of Sciences

    PNAS · 5 publications · 581 citations

    5

    h-index

1–5