Concepedia

Surface Loop Engineering

Surface Loop Engineering is a protein engineering strategy that involves the targeted modification of flexible polypeptide segments on the exterior of an enzyme to alter its functional or biophysical properties without disrupting the core catalytic architecture.

24

Publications

1.1K

Citations

107

Authors

47

Institutions

Publications per year

2017–2026

4

Parents

Publications

24

Correct Folding of Circularly Permuted Variants of a βα Barrel Enzyme in Vivo

Karolin Luger, Ulrich Hommel, Marzell Herold et al. · Science · 1989 · 211 citations

, , +17

Enhanced Activity and Altered Specificity of Phospholipase A <sub>2</sub> by Deletion of a Surface Loop

Oscar P. Kuipers, Marjolein Thunnissen, Pieter de Geus et al. · Science · 1989 · 99 citations · Full text

, , +16

Enhancement of a bacterial laccase thermostability through directed mutagenesis of a surface loop

Nasrin Mollania, Khosro Khajeh, Bijan Ranjbar et al. · Enzyme and Microbial Technology · 2011 · 76 citations

, , +8

Structure and function of the <i>Bacillus</i> hybrid enzyme GluXyn-1: Native-like jellyroll fold preserved after insertion of autonomous globular domain

Jacqueline Aÿ, Frank Götz, Rainer Borriss et al. · Proceedings of the National Academy of Sciences · 1998 · 66 citations · Full text

, , +17

A five-residue motif for the design of domain swapping in proteins

Neha Nandwani, Parag Surana, Hitendra Negi et al. · Nature Communications · 2019 · 63 citations · Full text

, , +16

1–5 of 24

Authors

107

  1. DM
    Diana M. Mitrea

    St. Jude Children's Research Hospital, United States

    2 publications · 69 citations

    2

    h-index

  2. SN
    Stewart N. Loh

    SUNY Upstate Medical University, United States

    2 publications · 69 citations

    2

    h-index

  3. RI
    Rosanto I. Paramban

    BD Biosciences (United States), United States

    1 publications · 35 citations

    1

    h-index

  4. AG
    Atsushi Goto

    Kyoto University, Japan

    1 publications · 27 citations

    1

    h-index

  5. AS
    Ariela Samantha

    The University of Western Australia, Australia

    1 publications · 19 citations

    1

    h-index

1–5 of 107

Institutions

47

  1. SUNY Upstate Medical University

    Syracuse, United States

    2 h-index

    8 publications

    271 citations

  2. University of Vermont

    Burlington, United States

    1 h-index

    3 publications

    129 citations

  3. UCLouvain

    Louvain-la-Neuve, Belgium

    1 h-index

    4 publications

    88 citations

  4. National Taiwan University of Science and Technology

    Taipei, Taiwan

    1 h-index

    1 publications

    36 citations

  5. Los Alamos National Laboratory

    Los Alamos, United States

    1 h-index

    4 publications

    152 citations

  6. Commonwealth Scientific and Industrial Research Organisation

    Canberra, Australia

    1 h-index

    1 publications

    30 citations

  7. University of Stuttgart

    Stuttgart, Germany

    1 h-index

    3 publications

    72 citations

  8. Tianjin Institute of Industrial Biotechnology

    Tianjin, China

    1 h-index

    4 publications

    144 citations

1–8 of 47

Venues

  1. Science

    2 publications · 310 citations

    2

    h-index

  2. Biochemistry

    2 publications · 54 citations

    2

    h-index

  3. Biochemical Journal

    BJ · 2 publications · 36 citations

    2

    h-index

  4. 2

    h-index

  5. Proceedings of the National Academy of Sciences

    PNAS · 2 publications · 103 citations

    2

    h-index

1–5