Concepedia

Substrate Discrimination

Substrate Discrimination is a biochemical mechanism by which an enzyme selectively identifies and binds a specific substrate among chemically similar molecules based on precise molecular complementarity and catalytic efficiency.

139

Publications

7.3K

Citations

664

Authors

262

Institutions

Publications per year

2017–2026

26

Parents

Publications

139

Structural basis of substrate discrimination and integrin binding by autotaxin

Jens Hausmann, Satwik Kamtekar, Evangelos Christodoulou et al. · Nature Structural & Molecular Biology · 2011 · 280 citations · Full text

, , +16

Design and characterization of a fluorogenic substrate selectively hydrolyzed by stromelysin 1 (matrix metalloproteinase-3).

Hideaki Nagase, Cynthia G. Fields, Gregg B. Fields · Journal of Biological Chemistry · 1994 · 246 citations · Full text

, , +13

An Evolved Aminoacyl-tRNA Synthetase with Atypical Polysubstrate Specificity,

Douglas D. Young, Travis S. Young, Michael Jahnz et al. · Biochemistry · 2011 · 226 citations · Full text

, , +15

The Structure of the Staphylococcus aureus Sortase-Substrate Complex Reveals How the Universally Conserved LPXTG Sorting Signal Is Recognized

Nuttee Suree, Chu Kong Liew, Valerie A. Villareal et al. · Journal of Biological Chemistry · 2009 · 218 citations · Full text

, , +17

Lon and Clp family proteases and chaperones share homologous substrate-recognition domains

Catherine K. Smith, Tania A. Baker, Robert T. Sauer · Proceedings of the National Academy of Sciences · 1999 · 189 citations · Full text

, , +17

1–5 of 139

Authors

664

  1. YA
    Yoshinori Akiyama

    Kyoto University, Japan

    3 publications · 83 citations

    3

    h-index

  2. YH
    Yohei Hizukuri

    Kyoto University, Japan

    3 publications · 83 citations

    3

    h-index

  3. SF
    Shinya Fushinobu

    The University of Tokyo, Japan

    2 publications · 129 citations

    2

    h-index

  4. MK
    Motomitsu Kitaoka

    Food Research Institute, Japan

    2 publications · 133 citations

    2

    h-index

  5. MJ
    Martina Jahn

    Technische Universität Braunschweig, Germany

    2 publications · 39 citations

    2

    h-index

1–5 of 664

Institutions

262

  1. Centre National de la Recherche Scientifique

    Paris, France

    6 h-index

    26 publications

    655 citations

  2. University of California, San Francisco

    San Francisco, United States

    5 h-index

    8 publications

    492 citations

  3. National Institutes of Health

    Bethesda, United States

    4 h-index

    14 publications

    591 citations

  4. Food Research Institute

    Tsukuba, Japan

    3 h-index

    10 publications

    597 citations

  5. The University of Tokyo

    Tokyo, Japan

    3 h-index

    6 publications

    416 citations

  6. Uppsala University

    Uppsala, Sweden

    3 h-index

    10 publications

    286 citations

  7. St. Jude Children's Research Hospital

    Memphis, United States

    3 h-index

    11 publications

    362 citations

  8. Kyoto University

    Kyoto, Japan

    3 h-index

    8 publications

    200 citations

1–8 of 262

Venues

  1. Journal of Biological Chemistry

    JBC · 23 publications · 1.5K citations

    20

    h-index

  2. Biochemistry

    14 publications · 924 citations

    12

    h-index

  3. Proceedings of the National Academy of Sciences

    PNAS · 11 publications · 613 citations

    11

    h-index

  4. ChemBioChem

    5 publications · 168 citations

    5

    h-index

  5. Nucleic Acids Research

    4 publications · 198 citations

    4

    h-index

1–5