Concepedia

Substrate Access Pathways

Substrate Access Pathways is a theoretical construct in enzymology that denotes the specific molecular channels or routes through which substrates migrate from the bulk solvent to the active site of an enzyme, thereby enabling catalytic activity.

172

Publications

10.2K

Citations

900

Authors

342

Institutions

Publications per year

2017–2026

35

Variants

Substrate Access ChannelsSubstrate Migration Pathways

Parents

Publications

172

Photoresponsive polymer–enzyme switches

Tsuyoshi Shimoboji, Edmund Larenas, Tim Fowler et al. · Proceedings of the National Academy of Sciences · 2002 · 317 citations

, , +17

Structural and functional divergence of insect CYP6B proteins: From specialist to generalist cytochrome P450

Xianchun Li, Jérôme Baudry, May R. Berenbaum et al. · Proceedings of the National Academy of Sciences · 2004 · 295 citations · Full text

, , +17

Open "Back Door" in a Molecular Dynamics Simulation of Acetylcholinesterase

Michael K. Gilson, Tjerk P. Straatsma, J. Andrew McCammon et al. · Science · 1994 · 262 citations

, , +17

Two Substrate Interaction Sites in Lignin Peroxidase Revealed by Site-Directed Mutagenesis

Wendy A. Doyle, Wolfgang Blodig, Nigel C. Veitch et al. · Biochemistry · 1998 · 248 citations · Full text

, , +12

The refined crystal structure of dimeric phospholipase A2 at 2.5 A. Access to a shielded catalytic center.

S. Brunie, Jeffrey T. Bolin, D.T. Gewirth et al. · Journal of Biological Chemistry · 1985 · 216 citations · Full text

, , +17

1–5 of 172

Authors

900

  1. JR
    James R. Halpert

    University of Arizona, United States

    4 publications · 147 citations

    4

    h-index

  2. RC
    Rebecca C. Wade

    Heidelberg Institute for Theoretical Studies, Germany

    4 publications · 396 citations

    4

    h-index

  3. KR
    Ke‐He Ruan

    The University of Texas Health Science Center at Houston, United States

    3 publications · 59 citations

    3

    h-index

  4. CS
    C.D. Stout

    Scripps Research Institute, United States

    3 publications · 197 citations

    3

    h-index

  5. HD
    Hui Deng

    Southern University of Science and Technology, China

    3 publications · 59 citations

    3

    h-index

1–5 of 900

Institutions

342

  1. Centre National de la Recherche Scientifique

    Paris, France

    11 h-index

    51 publications

    2.8K citations

  2. Scripps Research Institute

    San Diego, United States

    8 h-index

    37 publications

    1.9K citations

  3. University of California San Diego

    San Diego, United States

    6 h-index

    15 publications

    1.3K citations

  4. University of Toronto

    Toronto, Canada

    6 h-index

    39 publications

    3.4K citations

  5. Brookhaven National Laboratory

    Upton, United States

    5 h-index

    21 publications

    1.3K citations

  6. Massachusetts Institute of Technology

    Cambridge, United States

    5 h-index

    12 publications

    998 citations

  7. University of Oxford

    Oxford, United Kingdom

    5 h-index

    20 publications

    1.2K citations

  8. University of California, Los Angeles

    Los Angeles, United States

    5 h-index

    17 publications

    1.1K citations

1–8 of 342

Venues

  1. Biochemistry

    27 publications · 1.6K citations

    24

    h-index

  2. Journal of Biological Chemistry

    JBC · 17 publications · 1.2K citations

    16

    h-index

  3. Proceedings of the National Academy of Sciences

    PNAS · 14 publications · 1.7K citations

    14

    h-index

  4. Journal of the American Chemical Society

    JACS · 9 publications · 596 citations

    9

    h-index

  5. Proteins Structure Function and Bioinformatics

    5 publications · 225 citations

    5

    h-index

1–5