Concepedia

Structure-guided Protein Engineering

Structure-Guided Protein Engineering is a protein engineering approach that leverages high-resolution three-dimensional structural information of proteins to rationally design targeted modifications that enhance stability, activity, or specificity, distinguishing it from sequence-based or directed evolution methods by its reliance on atomic-level structural insights.

158

Publications

9.2K

Citations

863

Authors

260

Institutions

Publications per year

2017–2026

81

Variants

Structure-based Protein Engineering

Parents

Publications

158

Reverse engineering of the giant muscle protein titin

Hongbin Li, Wolfgang A. Linke, Andrés F. Oberhauser et al. · Nature · 2002 · 529 citations

, , +11

A Chemical Approach to Protein Design—Template‐Assembled Synthetic Proteins (TASP)

Manfred Mutter, Stéphane Vuilleumier · Angewandte Chemie International Edition in English · 1989 · 404 citations

, , +11

Structure-Guided Transformation of Channelrhodopsin into a Light-Activated Chloride Channel

A. Berndt, Soo Yeun Lee, Charu Ramakrishnan et al. · Science · 2014 · 390 citations · Full text

, , +17

A synthetic sex ratio distortion system for the control of the human malaria mosquito

Roberto Galizi, Lindsey Doyle, Miriam Menichelli et al. · Nature Communications · 2014 · 384 citations · Full text

, , +15

CyBase: a database of cyclic protein sequences and structures, with applications in protein discovery and engineering

Conan K. Wang, Quentin Kaas, L. Chiche et al. · Nucleic Acids Research · 2007 · 294 citations · Full text

, , +17

1–5 of 158

Authors

863

  1. YR
    Yijian Rao

    Jiangnan University, China

    3 publications · 149 citations

    4

    h-index

  2. FH
    Frances H. Arnold

    California Institute of Technology, United States

    3 publications · 316 citations

    3

    h-index

  3. UT
    Uwe T. Bornscheuer

    Universität Greifswald, Germany

    3 publications · 255 citations

    3

    h-index

  4. WZ
    Wenbin Zhang

    Peking University, China

    3 publications · 233 citations

    3

    h-index

  5. ZD
    Zhiwei Deng

    Central South University, China

    2 publications · 82 citations

    3

    h-index

1–5 of 863

Institutions

260

  1. Chinese Academy of Sciences

    Beijing, China

    7 h-index

    29 publications

    1K citations

  2. Jiangnan University

    Wuxi, China

    6 h-index

    29 publications

    1.3K citations

  3. East China University of Science and Technology

    Shanghai, China

    6 h-index

    36 publications

    806 citations

  4. Stanford University

    Stanford, United States

    5 h-index

    12 publications

    1.9K citations

  5. University of Washington

    Seattle, United States

    5 h-index

    22 publications

    1.9K citations

  6. University of Basel

    Basel, Switzerland

    4 h-index

    7 publications

    1.1K citations

  7. California Institute of Technology

    Pasadena, United States

    4 h-index

    15 publications

    1.4K citations

  8. Peking University

    Beijing, China

    4 h-index

    18 publications

    332 citations

1–8 of 260

Venues

  1. Chemical Communications

    ChemComm · 8 publications · 207 citations

    8

    h-index

  2. Nature Communications

    5 publications · 777 citations

    7

    h-index

  3. Proceedings of the National Academy of Sciences

    PNAS · 7 publications · 735 citations

    7

    h-index

  4. ACS Catalysis

    6 publications · 236 citations

    6

    h-index

  5. Journal of Biological Chemistry

    JBC · 5 publications · 323 citations

    6

    h-index

1–5