Concepedia

Structure-based Aptamer Design

Structure-Based Aptamer Design is a computational or experimental methodology in nucleic acid aptamer evolution that belongs to the class of rational design approaches, distinguished by its reliance on three-dimensional structural information of target molecules to guide the selection, prediction, or optimization of aptamers with high specificity and affinity.

17

Publications

838

Citations

142

Authors

77

Institutions

Publications per year

2017–2026

12

Parents

Publications

17

Selective optimization of the Rev-binding element of HIV-1

Lori Giver, David P. Bartel, Maria L. Zapp et al. · Nucleic Acids Research · 1993 · 121 citations · Full text

, , +17

Structure-guided post-SELEX optimization of an ochratoxin A aptamer

Guohua Xu, Jiajing Zhao, Na Liu et al. · Nucleic Acids Research · 2019 · 110 citations · Full text

, , +12

Structure-based investigation of fluorogenic Pepper aptamer

Kaiyi Huang, Xianjun Chen, Chunyan Li et al. · Nature Chemical Biology · 2021 · 91 citations

, , +8

Rational design of supramolecular hemin/G-quadruplex–dopamine aptamer nucleoapzyme systems with superior catalytic performance

Bauke Albada, Eyal Golub, Itamar Willner · Chemical Science · 2016 · 85 citations · Full text

, , +16

Design an aptasensor based on structure-switching aptamer on dendritic gold nanostructures/Fe3O4@SiO2/DABCO modified screen printed electrode for highly selective detection of epirubicin

Ayemeh Bagheri Hashkavayi, Jahan Bakhsh Raoof · Biosensors and Bioelectronics · 2017 · 73 citations

, , +13

1–5 of 17

Authors

142

  1. NA
    Nabeela A. Van

    Lehman College, United States

    1 publications · 27 citations

    1

    h-index

  2. GO
    Giorgia Oliviero

    University of Naples Federico II, Italy

    1 publications · 28 citations

    1

    h-index

  3. PV
    Polina V. Artyushenko

    Institute of Physics, Russia

    1 publications · 28 citations

    1

    h-index

  4. ZH
    Zefeng He

    Yangtze Normal University, China

    1 publications · 14 citations

    1

    h-index

  5. IT
    Ilaria Tortorella

    University of Perugia, Italy

    1 publications · 23 citations

    1

    h-index

1–5 of 142

Institutions

77

  1. Shanghai Jiao Tong University

    Shanghai, China

    2 h-index

    3 publications

    128 citations

  2. Chinese Academy of Sciences

    Beijing, China

    2 h-index

    9 publications

    952 citations

  3. Xiamen University

    Xiamen, China

    1 h-index

    2 publications

    56 citations

  4. Federico II University Hospital

    Naples, Italy

    1 h-index

    3 publications

    84 citations

  5. Institute of Physics

    Krasnoyarsk, Russia

    1 h-index

    3 publications

    84 citations

  6. East China University of Science and Technology

    Shanghai, China

    1 h-index

    4 publications

    364 citations

  7. Harvard University Press

    Cambridge, United States

    1 h-index

    1 publications

    121 citations

  8. Jiangnan University

    Wuxi, China

    1 h-index

    6 publications

    138 citations

1–8 of 77

Venues

  1. Nucleic Acids Research

    2 publications · 231 citations

    2

    h-index

  2. Journal of Chemical Information and Modeling

    JCIM · 2 publications · 44 citations

    2

    h-index

  3. Organic & Biomolecular Chemistry

    1 publications · 38 citations

    1

    h-index

  4. 1

    h-index

  5. Biophysical Chemistry

    BPC · 1 publications · 38 citations

    1

    h-index

1–5