Concepedia

Structure-based Active Site Design

Structure-Based Active Site Design is a computational and biochemical methodology within enzyme engineering that leverages high-resolution three-dimensional structural data of enzyme active sites to rationally design precise modifications that enhance or alter catalytic function.

89

Publications

4.5K

Citations

456

Authors

153

Institutions

Publications per year

2017–2026

17

Parents

Publications

89

Structure of the catalytic domain of human phosphodiesterase 5 with bound drug molecules

B.-J. Sung, Kwang Yeon Hwang, Young Ho Jeon et al. · Nature · 2003 · 278 citations

, , +16

Universal Catalytic Domain Structure of AdoMet-dependent Methyltransferases

Gerd Schluckebier, Margaret O’Gara, Wolfram Saenger et al. · Journal of Molecular Biology · 1995 · 244 citations

, , +13

Computational design of serine hydrolases

Anna Lauko, Samuel J. Pellock, Kiera H. Sumida et al. · Science · 2025 · 178 citations · Full text

, , +17

Crystal structures and inhibitor binding in the octameric flavoenzyme vanillyl-alcohol oxidase: the shape of the active-site cavity controls substrate specificity

Andrea Mattevi, Marco W. Fraaije, Andrea Mozzarelli et al. · Structure · 1997 · 172 citations · Full text

, , +16

Active site models for galactose oxidase and related enzymes

Shinobu Itoh, Masayasu Taki, Shunichi Fukuzumi · Coordination Chemistry Reviews · 2000 · 156 citations

, , +14

1–5 of 89

Authors

456

  1. KN
    K. N. Houk

    University of California, Los Angeles, United States

    3 publications · 235 citations

    3

    h-index

  2. SF
    Shunichi Fukuzumi

    The University of Osaka, Japan

    3 publications · 224 citations

    3

    h-index

  3. DB
    David Baker

    University of Washington, United States

    3 publications · 241 citations

    3

    h-index

  4. SI
    Shinobu Itoh

    The University of Osaka, Japan

    3 publications · 224 citations

    3

    h-index

  5. AT
    Adrian Tripp

    BioTechMed-Graz, Austria

    2 publications · 44 citations

    2

    h-index

1–5 of 456

Institutions

153

  1. University of Washington

    Seattle, United States

    5 h-index

    41 publications

    3.9K citations

  2. Lund University

    Lund, Sweden

    4 h-index

    8 publications

    416 citations

  3. Centre National de la Recherche Scientifique

    Paris, France

    3 h-index

    10 publications

    433 citations

  4. ETH Zurich

    Zurich, Switzerland

    3 h-index

    8 publications

    351 citations

  5. University of California, Los Angeles

    Los Angeles, United States

    3 h-index

    11 publications

    675 citations

  6. University of Graz

    Graz, Austria

    3 h-index

    7 publications

    181 citations

  7. Michigan State University

    East Lansing, United States

    3 h-index

    12 publications

    648 citations

  8. Graz University of Technology

    Graz, Austria

    3 h-index

    27 publications

    693 citations

1–8 of 153

Venues

  1. Journal of Molecular Biology

    JMB · 7 publications · 557 citations

    7

    h-index

  2. Bioorganic & Medicinal Chemistry Letters

    5 publications · 116 citations

    5

    h-index

  3. Chemical Communications

    ChemComm · 5 publications · 193 citations

    5

    h-index

  4. Angewandte Chemie International Edition

    3 publications · 258 citations

    3

    h-index

  5. Inorganic Chemistry

    3 publications · 72 citations

    3

    h-index

1–5