Concepedia

Strained Alkene Probes

Strained Alkene Probes is a fluorogenic bioorthogonal probe that consists of a twisted alkene moiety serving as a reactive, electron-deficient dienophile or dipolarophile, whose strain-promoted cycloaddition with specific complementary reagents results in fluorescence activation through relief of electronic quenching and concomitant formation of a rigidified adduct.

18

Publications

1.3K

Citations

53

Authors

26

Institutions

Publications per year

2017–2026

6

Variants

Strained Alkene Probe

Parents

Publications

18

Biomedical Applications of Tetrazine Cycloadditions

Neal K. Devaraj, Ralph Weissleder · Accounts of Chemical Research · 2011 · 512 citations · Full text

, , +17

Bioorthogonal Cycloadditions: Computational Analysis with the Distortion/Interaction Model and Predictions of Reactivities

Fang Liu, Yong Liang, K. N. Houk · Accounts of Chemical Research · 2017 · 193 citations · Full text

, , +8

Design of Spiro[2.3]hex-1-ene, a Genetically Encodable Double-Strained Alkene for Superfast Photoclick Chemistry

Zhipeng Yu, Qing Lin · Journal of the American Chemical Society · 2014 · 116 citations · Full text

, , +14

Light Harvesting for Rapid and Selective Reactions: Click Chemistry with Strain-Loadable Alkenes

Kamaljeet Singh, Christopher J. Fennell, Evangelos A. Coutsias et al. · Chem · 2017 · 73 citations · Full text

, , +14

Radical addition to strained olefins: a flexible access to small ring derivatives

Nicolas Legrand, Béatrice Quiclet‐Sire, Samir Z. Zard · Tetrahedron Letters · 2000 · 57 citations

, , +9

1–5 of 18

Authors

53

  1. BZ
    B. Zwanenburg

    Radboud University Nijmegen, Netherlands

    4 publications · 81 citations

    4

    h-index

  2. AK
    A.J.H. Klunder

    Radboud University Nijmegen, Netherlands

    4 publications · 81 citations

    4

    h-index

  3. ZY
    Zhipeng Yu

    Sichuan University, China

    2 publications · 160 citations

    2

    h-index

  4. NK
    Neal K. Devaraj

    University of California San Diego, United States

    2 publications · 530 citations

    2

    h-index

  5. BQ
    Béatrice Quiclet‐Sire

    École Polytechnique, France

    1 publications · 57 citations

    1

    h-index

1–5 of 53

Institutions

26

  1. Radboud University Nijmegen

    Nijmegen, The Netherlands

    5 h-index

    10 publications

    214 citations

  2. University of Wisconsin–Madison

    Madison, United States

    1 h-index

    3 publications

    159 citations

  3. Oklahoma State University

    Stillwater, United States

    1 h-index

    5 publications

    365 citations

  4. University of California, Riverside

    Riverside, United States

    1 h-index

    2 publications

    106 citations

  5. University of Parma

    Parma, Italy

    1 h-index

    3 publications

    39 citations

  6. University at Buffalo, State University of New York

    Buffalo, United States

    1 h-index

    2 publications

    232 citations

  7. Laboratoire de Synthèse Organique

    Palaiseau, France

    1 h-index

    1 publications

    57 citations

  8. University of California, Los Angeles

    Los Angeles, United States

    1 h-index

    2 publications

    386 citations

1–8 of 26

Venues

  1. Tetrahedron

    4 publications · 81 citations

    4

    h-index

  2. Chemical Communications

    ChemComm · 2 publications · 81 citations

    2

    h-index

  3. Tetrahedron Letters

    2 publications · 86 citations

    2

    h-index

  4. Synlett

    2 publications · 38 citations

    2

    h-index

  5. Accounts of Chemical Research

    2 publications · 705 citations

    2

    h-index

1–5