Stimuli-responsive biomaterials is a research field focused on the design, synthesis, and characterization of materials intended for interaction with biological systems that exhibit controlled changes in their physical, chemical, or biological properties in response to specific external or internal stimuli. This concept investigates the fundamental mechanisms governing these transformations (e.g., upon exposure to pH, temperature, redox potential, light, or enzymes) and explores their application potential for advanced biomedical technologies, including targeted drug delivery, diagnostics, and tissue engineering, leveraging their ability to provide precise, on-demand responses at pathological sites to enhance therapeutic efficacy and reduce systemic toxicity.