Concepedia

Steric Optimization

Steric Optimization is a computational or experimental strategy within medicinal chemistry that systematically modifies the spatial arrangement and bulk of molecular substituents to enhance bioisosteric equivalence by minimizing steric clashes and maximizing favorable interactions with biological targets.

217

Publications

11.1K

Citations

977

Authors

316

Institutions

Publications per year

2017–2026

50

Parents

Publications

217

Diarylprolinol Ethers: Expanding the Potential of Enamine/Iminium‐Ion Catalysis

Claudio Palomo, Antonia Mielgo · Angewandte Chemie International Edition · 2006 · 460 citations

, , +12

Comparative Investigation of Ruthenium-Based Metathesis Catalysts Bearing N-Heterocyclic Carbene (NHC) Ligands

Alois Fürstner, Lutz Ackermann, Barbara Gabor et al. · Chemistry - A European Journal · 2001 · 419 citations

, , +17

Mechanistic Investigation of the Staudinger Ligation

Fiona L. Lin, Helen M. Hoyt, Herman van Halbeek et al. · Journal of the American Chemical Society · 2005 · 369 citations

, , +13

The First N-Heterocyclic Carbene-Based Nickel Catalyst for C−S Coupling

Yugen Zhang, Kao Chin Ngeow, Jackie Y. Ying · Organic Letters · 2007 · 353 citations

, , +17

A Terminal Ni(III)−Imide with Diverse Reactivity Pathways

E. Kogut, Heather L. Wiencko, Libei Zhang et al. · Journal of the American Chemical Society · 2005 · 323 citations

, , +7

1–5 of 217

Authors

977

  1. LM
    Laurent Maron

    Laboratoire de Physique et Chimie des Nano-Objets, France

    3 publications · 67 citations

    3

    h-index

  2. FG
    Felipe Garcı́a

    University of Cambridge, United Kingdom

    3 publications · 183 citations

    3

    h-index

  3. FG
    Frank Glorius

    University of Münster, Germany

    3 publications · 393 citations

    3

    h-index

  4. VS
    Verena Streitferdt

    University of Regensburg, Germany

    2 publications · 57 citations

    2

    h-index

  5. RW
    Robert Wolf

    University of Regensburg, Germany

    2 publications · 57 citations

    2

    h-index

1–5 of 977

Institutions

316

  1. Centre National de la Recherche Scientifique

    Paris, France

    13 h-index

    43 publications

    2.2K citations

  2. Monash University

    Melbourne, Australia

    6 h-index

    20 publications

    786 citations

  3. Université Toulouse III - Paul Sabatier

    Toulouse, France

    6 h-index

    22 publications

    786 citations

  4. Chinese Academy of Sciences

    Beijing, China

    6 h-index

    21 publications

    932 citations

  5. University of Stuttgart

    Stuttgart, Germany

    5 h-index

    14 publications

    436 citations

  6. Université Fédérale de Toulouse Midi-Pyrénées

    Toulouse, France

    5 h-index

    13 publications

    561 citations

  7. Laboratoire de Chimie de Coordination

    Toulouse, France

    4 h-index

    11 publications

    583 citations

  8. The University of Queensland

    Brisbane, Australia

    4 h-index

    6 publications

    482 citations

1–8 of 316

Venues

  1. Journal of the American Chemical Society

    JACS · 14 publications · 2.2K citations

    14

    h-index

  2. Inorganic Chemistry

    13 publications · 620 citations

    13

    h-index

  3. Chemical Communications

    ChemComm · 13 publications · 493 citations

    12

    h-index

  4. Dalton Transactions

    12 publications · 348 citations

    11

    h-index

  5. The Journal of Organic Chemistry

    JOC · 11 publications · 372 citations

    11

    h-index

1–5