Concepedia

Spo11-mediated Breaks

Spo11-Mediated Breaks is a molecular genetic phenomenon in which the evolutionarily conserved topoisomerase-like protein Spo11 catalyzes the formation of programmed double-strand breaks in DNA during prophase I of meiosis, thereby initiating homologous recombination and ensuring proper chromosome segregation.

78

Publications

8.7K

Citations

388

Authors

184

Institutions

Publications per year

2017–2026

28

Variants

Spo11-mediated Double-strand Breaks

Parents

Publications

78

Meiosis-Specific DNA Double-Strand Breaks Are Catalyzed by Spo11, a Member of a Widely Conserved Protein Family

Scott Keeney, Craig N. Giroux, Nancy Kleckner · Cell · 1997 · 1.9K citations · Full text

, , +11

Meiotic Recombination in C. elegans Initiates by a Conserved Mechanism and Is Dispensable for Homologous Chromosome Synapsis

Abby F. Dernburg, Kent McDonald, Gary Moulder et al. · Cell · 1998 · 799 citations · Full text

, , +17

Spo11-Accessory Proteins Link Double-Strand Break Sites to the Chromosome Axis in Early Meiotic Recombination

Silvia Panizza, Marco Antonio Mendoza-Parra, Marc Berlinger et al. · Cell · 2011 · 396 citations · Full text

, , +15

Spo11 and the Formation of DNA Double-Strand Breaks in Meiosis

Scott Keeney · Genome dynamics and stability · 2007 · 340 citations

, , +12

The TopoVIB-Like protein family is required for meiotic DNA double-strand break formation

Thomas Robert, Alexandre Nore, Christine Brun et al. · Science · 2016 · 316 citations

, , +14

1–5 of 78

Authors

388

  1. SK
    Scott Keeney

    Memorial Sloan Kettering Cancer Center, United States

    9 publications · 2.7K citations

    9

    h-index

  2. AN
    Alain Nicolas

    Institut Curie, France

    6 publications · 645 citations

    6

    h-index

  3. KO
    Kunihiro Ohta

    The University of Tokyo, Japan

    4 publications · 268 citations

    4

    h-index

  4. RD
    R. Daniel Camerini‐Otero

    National Institutes of Health, United States

    4 publications · 449 citations

    4

    h-index

  5. TS
    Takehiko Shibata

    RIKEN, Japan

    4 publications · 200 citations

    4

    h-index

1–5 of 388

Institutions

184

  1. Centre National de la Recherche Scientifique

    Paris, France

    13 h-index

    52 publications

    7K citations

  2. Memorial Sloan Kettering Cancer Center

    New York, United States

    9 h-index

    20 publications

    1.9K citations

  3. Inserm

    Paris, France

    8 h-index

    19 publications

    2K citations

  4. Cornell University

    Ithaca, United States

    7 h-index

    17 publications

    1.3K citations

  5. University of Vienna

    Vienna, Austria

    7 h-index

    26 publications

    3.2K citations

  6. Institut Curie

    Paris, France

    6 h-index

    17 publications

    2.3K citations

  7. Howard Hughes Medical Institute

    Chevy Chase, United States

    6 h-index

    11 publications

    980 citations

  8. Max Perutz Labs

    Vienna, Austria

    5 h-index

    20 publications

    2.9K citations

1–8 of 184

Venues

  1. PLoS Genetics

    6 publications · 308 citations

    6

    h-index

  2. Nucleic Acids Research

    5 publications · 313 citations

    5

    h-index

  3. The Plant Journal

    5 publications · 418 citations

    5

    h-index

  4. Proceedings of the National Academy of Sciences

    PNAS · 4 publications · 304 citations

    4

    h-index

  5. Molecular and Cellular Biology

    MCB · 4 publications · 229 citations

    4

    h-index

1–5