Spill prevention is an interdisciplinary research field and methodological approach dedicated to the systematic identification, assessment, and control of factors contributing to the unintended release of potentially harmful substances into the environment or workspaces. It encompasses the investigation of root causes and failure mechanisms, the design and implementation of engineering controls and containment systems, the development of operational procedures, and the establishment of regulatory frameworks aimed at proactively averting spills and mitigating their adverse environmental, safety, and economic consequences.