Concepedia

Spatial Multi-modal Profiling

Spatial Multi-Modal Profiling is a computational and experimental framework that enables the simultaneous acquisition and integration of multiple molecular data types—such as genomics, transcriptomics, and proteomics—with high-resolution spatial context to resolve the architectural and functional organization of biological tissues at single-cell or subcellular resolution.

11

Publications

497

Citations

71

Authors

34

Institutions

Publications per year

2017–2026

11

Parents

Publications

11

Spatial genomics enables multi-modal study of clonal heterogeneity in tissues

Tongtong Zhao, Zachary Chiang, Julia W. Morriss et al. · Nature · 2021 · 270 citations · Full text

, , +14

Resolving tissue complexity by multimodal spatial omics modeling with MISO

Kyle Coleman, Amelia Schroeder, Melanie Loth et al. · Nature Methods · 2025 · 60 citations · Full text

, , +14

Deep learning in spatial transcriptomics: Learning from the next next-generation sequencing

A. Ali Heydari, Suzanne Sindi · Biophysics Reviews · 2023 · 31 citations · Full text

, , +15

Identifying temporal and spatial patterns of variation from multi-modal data using MEFISTO

Britta Velten, Jana M. Braunger, Damien Arnol et al. · bioRxiv (Cold Spring Harbor Laboratory) · 2020 · 27 citations · Full text

, , +12

Tissue characterization at an enhanced resolution across spatial omics platforms with deep generative model

Bohan Li, Feng Bao, Yimin Hou et al. · Nature Communications · 2024 · 25 citations · Full text

, , +16

1–5 of 11

Authors

71

  1. FC
    Fei Chen

    Broad Institute, United States

    2 publications · 288 citations

    2

    h-index

  2. NN
    Naeem Nadaf

    Broad Institute, United States

    2 publications · 288 citations

    2

    h-index

  3. LW
    Linghua Wang

    The University of Texas MD Anderson Cancer Center, United States

    1 publications · 60 citations

    2

    h-index

  4. AA
    A. Ali Heydari

    University of California, Merced, United States

    2 publications · 49 citations

    2

    h-index

  5. SS
    Suzanne Sindi

    University of California, Merced, United States

    2 publications · 49 citations

    2

    h-index

1–5 of 71

Institutions

34

  1. Harvard University

    Cambridge, United States

    3 h-index

    17 publications

    2.4K citations

  2. Massachusetts General Hospital

    Boston, United States

    2 h-index

    2 publications

    288 citations

  3. Massachusetts Institute of Technology

    Cambridge, United States

    2 h-index

    5 publications

    1.1K citations

  4. University of California, Merced

    Merced, United States

    2 h-index

    4 publications

    98 citations

  5. Broad Institute

    Cambridge, United States

    2 h-index

    28 publications

    3.5K citations

  6. The University of Texas Health Science Center at Houston

    Houston, United States

    2 h-index

    2 publications

    120 citations

  7. The University of Texas MD Anderson Cancer Center

    Houston, United States

    2 h-index

    5 publications

    300 citations

  8. Ludwig Cancer Research

    New York, United States

    1 h-index

    2 publications

    120 citations

1–8 of 34

Venues

  1. Nature Communications

    1 publications · 25 citations

    3

    h-index

  2. bioRxiv (Cold Spring Harbor Laboratory)

    Repository · 3 publications · 63 citations

    3

    h-index

  3. Biophysics Reviews

    BPR · 1 publications · 31 citations

    1

    h-index

  4. Nature

    1 publications · 270 citations

    1

    h-index

  5. Nature Methods

    1 publications · 60 citations

    1

    h-index

1–5