Concepedia

Solid-phase Combinatorial Synthesis

Solid-Phase Combinatorial Synthesis is a method in organic and medicinal chemistry that belongs to the class of combinatorial synthesis techniques, distinguished by its use of an insoluble solid support to enable the parallel and stepwise assembly of diverse molecular libraries through iterative chemical reactions and purification-free intermediates.

297

Publications

12.2K

Citations

925

Authors

243

Institutions

Publications per year

2017–2026

7

Parents

Publications

297

Approaches to Combinatorial Synthesis of Heterocycles:  A Solid-Phase Synthesis of 1,4-Dihydropyridines

M. F. GORDEEV, Dinesh V. Patel, Eric M. Gordon · The Journal of Organic Chemistry · 1996 · 252 citations

, , +17

A solid phase protocol of the biginelli dihydropyrimidine synthesis suitable for combinatorial chemistry

Peter Wipf, April M. Cunningham · Tetrahedron Letters · 1995 · 230 citations

, , +14

Reagents for Combinatorial Organic Synthesis: Development of a New o-Nitrobenzyl Photolabile Linker for Solid Phase Synthesis

Christopher P. Holmes, David Jones · The Journal of Organic Chemistry · 1995 · 211 citations

, , +10

Discovery and characterization of OC144-093, a novel inhibitor of P-glycoprotein-mediated multidrug resistance.

Michael Newman, Jennifer C. Rodarte, Khalid Benbatoul et al. · PubMed · 2000 · 191 citations

, , +14

Solid‐Phase Syntheses of Unnatural Biopolymers Containing Repeating Urea Units

Kevin Burgess, Hunwoo Shin, D. Scott Linthicum · Angewandte Chemie International Edition in English · 1995 · 182 citations

, , +13

1–5 of 297

Authors

925

  1. MM
    Morten Meldal

    Carlsberg Laboratory, Denmark

    11 publications · 369 citations

    10

    h-index

  2. TT
    Takashi Takahashi

    Tokyo Institute of Technology, Japan

    8 publications · 163 citations

    8

    h-index

  3. FA
    Fernando Alberício

    Universitat de Barcelona, Spain

    7 publications · 189 citations

    7

    h-index

  4. SB
    Stefan Bräse

    Karlsruhe Institute of Technology, Germany

    7 publications · 366 citations

    7

    h-index

  5. TD
    Takayuki Doi

    Tokyo Institute of Technology, Japan

    6 publications · 139 citations

    6

    h-index

1–5 of 925

Institutions

243

  1. Scripps Research Institute

    San Diego, United States

    11 h-index

    40 publications

    3.5K citations

  2. Carlsberg Laboratory

    Copenhagen, Denmark

    10 h-index

    31 publications

    1.4K citations

  3. University of California San Diego

    San Diego, United States

    9 h-index

    27 publications

    2.2K citations

  4. Universitat de Barcelona

    Barcelona, Spain

    7 h-index

    30 publications

    683 citations

  5. National University of Singapore

    Singapore, Singapore

    7 h-index

    23 publications

    940 citations

  6. University of Cambridge

    Cambridge, United Kingdom

    7 h-index

    22 publications

    971 citations

  7. Karlsruhe Institute of Technology

    Karlsruhe, Germany

    7 h-index

    28 publications

    817 citations

  8. Tokyo Institute of Technology

    Tokyo, Japan

    7 h-index

    27 publications

    655 citations

1–8 of 243

Venues

  1. Tetrahedron Letters

    40 publications · 1.7K citations

    26

    h-index

  2. Journal of Combinatorial Chemistry

    56 publications · 1.6K citations

    24

    h-index

  3. Angewandte Chemie International Edition

    17 publications · 1.1K citations

    16

    h-index

  4. The Journal of Organic Chemistry

    JOC · 16 publications · 1.2K citations

    15

    h-index

  5. Bioorganic & Medicinal Chemistry Letters

    12 publications · 468 citations

    11

    h-index

1–5