Smart biomaterials is a research field dedicated to the design, synthesis, and application of materials engineered to exhibit dynamic, tunable responses to specific biological or external stimuli within living systems. This concept investigates the intricate interplay between material properties and biological environments, focusing on developing materials that can sense changes (e.g., pH, temperature, chemical signals, light) and undergo controlled alterations in their physical, chemical, or functional characteristics (e.g., shape change, controlled release, altered surface chemistry). Its significance lies in enabling advanced biomedical applications, such as targeted drug delivery, responsive tissue engineering scaffolds, and sophisticated biosensing platforms, by providing materials capable of active, context-dependent interaction with biological processes.