Concepedia

Signal Desensitization

Signal Desensitization is a cellular regulatory process in signal transduction whereby sustained or repeated stimulation of a receptor or signaling pathway leads to a diminished cellular response, typically through receptor modification, sequestration, downregulation, or engagement of inhibitory feedback mechanisms.

125

Publications

7.6K

Citations

384

Authors

148

Institutions

Publications per year

2017–2026

2

Parents

Children

Publications

125

Receptor clustering as a cellular mechanism to control sensitivity

Dennis Bray, Matthew D. Levin, Carl J. Morton-Firth · Nature · 1998 · 625 citations

, , +13

Rapid shuttling of NF-AT in discrimination of Ca2+ signals and immunosuppression

Luika Timmerman, Neil A. Clipstone, Steffan N. Ho et al. · Nature · 1996 · 527 citations

, , +14

Multiple pathways of rapid beta 2-adrenergic receptor desensitization. Delineation with specific inhibitors.

Martin J. Lohse, J.L. Benovic, M G Caron et al. · Journal of Biological Chemistry · 1990 · 398 citations · Full text

, , +14

Sequestration and recycling of beta 2-adrenergic receptors permit receptor resensitization.

Susanne Pippig, S Andexinger, Martin J. Lohse · Molecular Pharmacology · 1995 · 352 citations

, , +16

A Model Based on Receptor Desensitization for Cyclic AMP Signaling in Dictyostelium Cells

Jean‐Louis Martiel, Albert Goldbeter · Biophysical Journal · 1987 · 307 citations · Full text

, , +16

1–5 of 125

Authors

384

  1. RJ
    Robert J. Lefkowitz

    Duke Medical Center, United States

    5 publications · 924 citations

    5

    h-index

  2. PH
    Peter H. Fishman

    National Institute of Neurological Disorders and Stroke, United States

    4 publications · 146 citations

    4

    h-index

  3. RI
    Ravi Iyengar

    Icahn School of Medicine at Mount Sinai, United States

    3 publications · 226 citations

    3

    h-index

  4. AG
    Albert Goldbeter

    Université Libre de Bruxelles, Belgium

    3 publications · 374 citations

    3

    h-index

  5. PS
    Paul-Michael Salomonsky

    Eastern Virginia Medical School, United States

    2 publications · 24 citations

    2

    h-index

1–5 of 384

Institutions

148

  1. Howard Hughes Medical Institute

    Chevy Chase, United States

    8 h-index

    20 publications

    5.5K citations

  2. Duke Medical Center

    Durham, United States

    6 h-index

    20 publications

    3.1K citations

  3. National Institutes of Health

    Bethesda, United States

    6 h-index

    11 publications

    606 citations

  4. Duke University Hospital

    Durham, United States

    6 h-index

    20 publications

    3.1K citations

  5. National Institute of Neurological Disorders and Stroke

    Bethesda, United States

    3 h-index

    6 publications

    206 citations

  6. University of North Carolina at Chapel Hill

    Chapel Hill, United States

    3 h-index

    7 publications

    341 citations

  7. Baylor College of Medicine

    Houston, United States

    3 h-index

    9 publications

    720 citations

  8. Bulgarian Academy of Sciences

    Sofia, Bulgaria

    2 h-index

    10 publications

    395 citations

1–8 of 148

Venues

  1. Journal of Biological Chemistry

    JBC · 13 publications · 1.2K citations

    13

    h-index

  2. Molecular Pharmacology

    6 publications · 685 citations

    6

    h-index

  3. PubMed

    Repository · 6 publications · 269 citations

    6

    h-index

  4. Endocrinology

    5 publications · 124 citations

    5

    h-index

  5. European Journal of Pharmacology

    EJP · 5 publications · 82 citations

    5

    h-index

1–5