Concepedia

Siglec Binding

Siglec Binding is a molecular recognition event in which sialic acid-binding immunoglobulin-like lectins (Siglecs) selectively engage sialoglycan epitopes on glycoproteins or glycolipids, thereby mediating cell-specific carbohydrate-protein interactions critical to immune regulation and pathogen detection.

267

Publications

20.4K

Citations

1.5K

Authors

486

Institutions

Publications per year

2017–2026

100

Parents

Publications

267

CD24 signalling through macrophage Siglec-10 is a target for cancer immunotherapy

Amira Barkal, Rachel Brewer, Maxim Markovic et al. · Nature · 2019 · 1.4K citations

, , +14

Glycocalyx engineering reveals a Siglec-based mechanism for NK cell immunoevasion

Jason E. Hudak, Stephen M. Canham, Carolyn R. Bertozzi · Nature Chemical Biology · 2013 · 495 citations · Full text

, , +16

Molecular mimicry of host sialylated glycans allows a bacterial pathogen to engage neutrophil Siglec-9 and dampen the innate immune response

Aaron F. Carlin, Satoshi Uchiyama, Yung‐Chi Chang et al. · Blood · 2009 · 402 citations · Full text

, , +17

Uniquely human evolution of sialic acid genetics and biology

Ajit Varki · Proceedings of the National Academy of Sciences · 2010 · 277 citations · Full text

, , +15

Glycan Array Screening Reveals a Candidate Ligand for Siglec-8*

Bruce S. Bochner, Richard Alvarez, Padmaja Mehta et al. · Journal of Biological Chemistry · 2004 · 262 citations · Full text

, , +17

1–5 of 267

Authors

1.5K

  1. PR
    Paul R. Crocker

    University of Dundee, United Kingdom

    55 publications · 5.3K citations

    44

    h-index

  2. AV
    Ajit Varki

    University of California San Diego, United States

    29 publications · 3.5K citations

    27

    h-index

  3. JC
    James C. Paulson

    Scripps Research Institute, United States

    24 publications · 2.4K citations

    21

    h-index

  4. RL
    Ronald L. Schnaar

    Johns Hopkins University, United States

    12 publications · 1K citations

    12

    h-index

  5. VN
    Victor Nizet

    University of California San Diego, United States

    12 publications · 1.5K citations

    12

    h-index

1–5 of 1.5K

Institutions

486

  1. University of Dundee

    Dundee, United Kingdom

    44 h-index

    113 publications

    11.9K citations

  2. University of California San Diego

    San Diego, United States

    29 h-index

    148 publications

    15K citations

  3. Wellcome Trust

    London, United Kingdom

    26 h-index

    63 publications

    7.9K citations

  4. Scripps Research Institute

    San Diego, United States

    23 h-index

    106 publications

    10.3K citations

  5. Johns Hopkins University

    Baltimore, United States

    17 h-index

    74 publications

    5.8K citations

  6. Johns Hopkins Medicine

    Baltimore, United States

    15 h-index

    60 publications

    4.9K citations

  7. University of Alberta

    Edmonton, Canada

    10 h-index

    69 publications

    4.3K citations

  8. Heidelberg University

    Heidelberg, Germany

    9 h-index

    17 publications

    1K citations

1–8 of 486

Venues

  1. Journal of Biological Chemistry

    JBC · 30 publications · 3.1K citations

    28

    h-index

  2. Glycobiology

    16 publications · 1.3K citations

    16

    h-index

  3. Frontiers in Immunology

    14 publications · 505 citations

    14

    h-index

  4. The Journal of Immunology

    JI · 12 publications · 1K citations

    11

    h-index

  5. Proceedings of the National Academy of Sciences

    PNAS · 11 publications · 1.6K citations

    11

    h-index

1–5