Concepedia

Side Chain Replacement

Side Chain Replacement is a molecular modification strategy in medicinal chemistry whereby a substituent group on a core scaffold is systematically substituted with a structurally or functionally analogous moiety to preserve the pharmacophoric features essential for biological activity.

95

Publications

4.2K

Citations

590

Authors

177

Institutions

Publications per year

2017–2026

14

Parents

Publications

95

Structure-Activity Relationships of Indole- and Pyrrole-Derived Cannabinoids

Jenny L. Wiley, Julia A.H. Lainton, John W. Huffman et al. · Journal of Pharmacology and Experimental Therapeutics · 1998 · 242 citations

, , +14

Replacing Alkyl with Oligo(ethylene glycol) as Side Chains of Conjugated Polymers for Close π–π Stacking

Bin Meng, Haiyang Song, Xingxing Chen et al. · Macromolecules · 2015 · 185 citations

, , +17

The Stability of Holomyoglobin Is Determined by Heme Affinity

Mark S. Hargrove, John S. Olson · Biochemistry · 1996 · 183 citations

, , +13

Uncoupling and Turnover in a Cl−/H+ Exchange Transporter

Michael Walden, Alessio Accardi, Fang Wu et al. · The Journal of General Physiology · 2007 · 138 citations · Full text

, , +14

Mutations in lambda repressor's amino-terminal domain: implications for protein stability and DNA binding.

Michael H. Hecht, Hillary C.M. Nelson, Robert T. Sauer · Proceedings of the National Academy of Sciences · 1983 · 138 citations · Full text

, , +14

1–5 of 95

Authors

590

  1. AW
    Akimori Wada

    Kobe Pharmaceutical University, Japan

    2 publications · 55 citations

    2

    h-index

  2. YS
    Yoshitomo Suhara

    Kobe Pharmaceutical University, Japan

    2 publications · 55 citations

    2

    h-index

  3. JJ
    Jia Jia

    Nanjing Medical University, China

    2 publications · 55 citations

    2

    h-index

  4. MW
    Masato Watanabe

    Teikyo University, Japan

    2 publications · 55 citations

    2

    h-index

  5. KN
    Kimie Nakagawa

    Kobe Pharmaceutical University, Japan

    2 publications · 55 citations

    2

    h-index

1–5 of 590

Institutions

177

  1. Chinese Academy of Sciences

    Beijing, China

    4 h-index

    32 publications

    1.9K citations

  2. Howard Hughes Medical Institute

    Chevy Chase, United States

    3 h-index

    15 publications

    1.1K citations

  3. University of Chicago

    Chicago, United States

    3 h-index

    10 publications

    657 citations

  4. Kyoto University

    Kyoto, Japan

    3 h-index

    11 publications

    428 citations

  5. South China University of Technology

    Guangzhou, China

    3 h-index

    18 publications

    799 citations

  6. Kobe Pharmaceutical University

    Kobe, Japan

    3 h-index

    13 publications

    374 citations

  7. University of California, San Francisco

    San Francisco, United States

    3 h-index

    6 publications

    408 citations

  8. Karolinska Institutet

    Stockholm, Sweden

    3 h-index

    8 publications

    250 citations

1–8 of 177

Venues

  1. Journal of Medicinal Chemistry

    13 publications · 525 citations

    11

    h-index

  2. Biochemistry

    9 publications · 438 citations

    9

    h-index

  3. Journal of Biological Chemistry

    JBC · 7 publications · 355 citations

    7

    h-index

  4. European Journal of Biochemistry

    EJB · 4 publications · 157 citations

    4

    h-index

  5. Journal of the American Chemical Society

    JACS · 4 publications · 109 citations

    4

    h-index

1–5