Concepedia

Separase Regulation

Separase Regulation is a biochemical control mechanism that governs the activation and inhibition of separase, a protease responsible for cleaving cohesin complexes to enable sister chromatid separation during mitosis, ensuring proper chromosome segregation through targeted protein interactions and post-translational modifications.

142

Publications

9.9K

Citations

598

Authors

217

Institutions

Publications per year

2017–2026

24

Parents

Publications

142

Cohesin Cleavage by Separase Required for Anaphase and Cytokinesis in Human Cells

Silke Hauf, Irene C. Waizenegger, Jan‐Michael Peters · Science · 2001 · 506 citations

, , +17

Separase, Polo Kinase, the Kinetochore Protein Slk19, and Spo12 Function in a Network that Controls Cdc14 Localization during Early Anaphase

Frank Stegmeier, Rosella Visintin, Angelika Amon · Cell · 2002 · 439 citations · Full text

, , +16

Polo Kinase and Separase Regulate the Mitotic Licensing of Centriole Duplication in Human Cells

Meng-Fu Bryan Tsou, Won‐Jing Wang, Kelly A. George et al. · Developmental Cell · 2009 · 300 citations · Full text

, , +15

Human Bub1 protects centromeric sister-chromatid cohesion through Shugoshin during mitosis

Zhanyun Tang, Yuxiao Sun, Sara E. Harley et al. · Proceedings of the National Academy of Sciences · 2004 · 265 citations · Full text

, , +17

Downregulation of PP2ACdc55 Phosphatase by Separase Initiates Mitotic Exit in Budding Yeast

Ethel Queralt, Chris Lehane, Béla Novák et al. · Cell · 2006 · 253 citations · Full text

, , +14

1–5 of 142

Authors

598

  1. OS
    Olaf Stemmann

    Max Planck Institute of Biochemistry, Germany

    14 publications · 834 citations

    14

    h-index

  2. MY
    Mitsuhiro Yanagida

    Kyoto University, Japan

    9 publications · 438 citations

    9

    h-index

  3. DP
    Debananda Pati

    Children's Cancer Center, United States

    8 publications · 426 citations

    8

    h-index

  4. KN
    Kim Nasmyth

    Research Institute of Molecular Pathology, Austria

    6 publications · 899 citations

    6

    h-index

  5. SH
    Susanne Hellmuth

    University of Bayreuth, Germany

    6 publications · 316 citations

    6

    h-index

1–5 of 598

Institutions

217

  1. University of Bayreuth

    Bayreuth, Germany

    13 h-index

    42 publications

    2.5K citations

  2. Baylor College of Medicine

    Houston, United States

    12 h-index

    62 publications

    4.2K citations

  3. Max Planck Institute of Biochemistry

    Martinsried, Germany

    9 h-index

    24 publications

    2.2K citations

  4. Kyoto University

    Kyoto, Japan

    8 h-index

    27 publications

    1.4K citations

  5. Children's Cancer Center

    Tampa, United States

    8 h-index

    41 publications

    2.9K citations

  6. The University of Texas Southwestern Medical Center

    Dallas, United States

    8 h-index

    18 publications

    2K citations

  7. Research Institute of Molecular Pathology

    Vienna, Austria

    8 h-index

    27 publications

    5.8K citations

  8. Centre National de la Recherche Scientifique

    Paris, France

    7 h-index

    40 publications

    2.7K citations

1–8 of 217

Venues

  1. Cell Cycle

    14 publications · 540 citations

    14

    h-index

  2. The Journal of Cell Biology

    JCB · 10 publications · 819 citations

    10

    h-index

  3. Genes & Development

    8 publications · 579 citations

    8

    h-index

  4. Nature

    7 publications · 531 citations

    7

    h-index

  5. PLoS ONE

    5 publications · 129 citations

    5

    h-index

1–5