Concepedia

Separase Activation

Separase Activation is a biochemical regulatory event, belonging to the class of cell cycle control mechanisms, that specifically involves the proteolytic activation of the separase enzyme through cleavage of its inhibitory securin subunit, thereby triggering sister chromatid separation during anaphase.

97

Publications

7.7K

Citations

378

Authors

144

Institutions

Publications per year

2017–2026

17

Parents

Publications

97

Cohesin Cleavage by Separase Required for Anaphase and Cytokinesis in Human Cells

Silke Hauf, Irene C. Waizenegger, Jan‐Michael Peters · Science · 2001 · 506 citations

, , +17

Separase, Polo Kinase, the Kinetochore Protein Slk19, and Spo12 Function in a Network that Controls Cdc14 Localization during Early Anaphase

Frank Stegmeier, Rosella Visintin, Angelika Amon · Cell · 2002 · 439 citations · Full text

, , +16

Cell-Type-Specific TEV Protease Cleavage Reveals Cohesin Functions in Drosophila Neurons

Andrea Pauli, Friederike Althoff, Raquel A. Oliveira et al. · Developmental Cell · 2008 · 302 citations · Full text

, , +16

Polo Kinase and Separase Regulate the Mitotic Licensing of Centriole Duplication in Human Cells

Meng-Fu Bryan Tsou, Won‐Jing Wang, Kelly A. George et al. · Developmental Cell · 2009 · 300 citations · Full text

, , +15

Downregulation of PP2ACdc55 Phosphatase by Separase Initiates Mitotic Exit in Budding Yeast

Ethel Queralt, Chris Lehane, Béla Novák et al. · Cell · 2006 · 253 citations · Full text

, , +14

1–5 of 97

Authors

378

  1. OS
    Olaf Stemmann

    Max Planck Institute of Biochemistry, Germany

    9 publications · 662 citations

    9

    h-index

  2. DP
    Debananda Pati

    Children's Cancer Center, United States

    6 publications · 353 citations

    6

    h-index

  3. SH
    Stefan Heidmann

    University of Bayreuth, Germany

    6 publications · 611 citations

    6

    h-index

  4. FU
    Frank Uhlmann

    The Francis Crick Institute, United Kingdom

    5 publications · 773 citations

    5

    h-index

  5. NZ
    Nenggang Zhang

    Children's Cancer Center, United States

    5 publications · 328 citations

    5

    h-index

1–5 of 378

Institutions

144

  1. University of Bayreuth

    Bayreuth, Germany

    9 h-index

    25 publications

    1.9K citations

  2. Baylor College of Medicine

    Houston, United States

    8 h-index

    45 publications

    3.3K citations

  3. Max Planck Institute of Biochemistry

    Martinsried, Germany

    7 h-index

    23 publications

    2.3K citations

  4. Research Institute of Molecular Pathology

    Vienna, Austria

    7 h-index

    18 publications

    4.4K citations

  5. Children's Cancer Center

    Tampa, United States

    6 h-index

    36 publications

    2.6K citations

  6. Heidelberg University

    Heidelberg, Germany

    6 h-index

    37 publications

    561 citations

  7. Centre National de la Recherche Scientifique

    Paris, France

    5 h-index

    38 publications

    2.5K citations

  8. The University of Texas Southwestern Medical Center

    Dallas, United States

    5 h-index

    10 publications

    657 citations

1–8 of 144

Venues

  1. Cell Cycle

    9 publications · 349 citations

    9

    h-index

  2. The Journal of Cell Biology

    JCB · 7 publications · 477 citations

    7

    h-index

  3. Nature

    6 publications · 474 citations

    6

    h-index

  4. Nature Communications

    5 publications · 260 citations

    5

    h-index

  5. Current Biology

    5 publications · 774 citations

    5

    h-index

1–5