Concepedia

Self-cleaving Ribozymes

Self-Cleaving Ribozymes is a class of catalytic RNA molecules that mediate site-specific cleavage of their own phosphodiester backbone without the requirement for external protein enzymes, thereby exhibiting intrinsic ribonuclease activity.

285

Publications

17.8K

Citations

764

Authors

297

Institutions

Publications per year

2017–2026

46

Parents

Publications

285

Ribozymes as Potential Anti-HIV-1 Therapeutic Agents

Nava Sarver, Edouard M. Cantin, Pairoj S. Chang et al. · Science · 1990 · 663 citations

, , +15

Sequence requirements of the hammerhead RNA self-cleavage reaction

Duane E. Ruffner, Gary D. Stormo, Olke C. Uhlenbeck · Biochemistry · 1990 · 471 citations

, , +11

Deadenylation is a widespread effect of miRNA regulation

Ana Eulálio, Eric Huntzinger, Tadashi Nishihara et al. · RNA · 2008 · 428 citations · Full text

, , +17

General Acid-Base Catalysis in the Mechanism of a Hepatitis Delta Virus Ribozyme

Shu‐ichi Nakano, Durga M. Chadalavada, Philip C. Bevilacqua · Science · 2000 · 388 citations

, , +17

Rational design of allosteric ribozymes

Jin Tang, Ronald R. Breaker · Chemistry & Biology · 1997 · 374 citations · Full text

, , +17

1–5 of 285

Authors

764

  1. RR
    Ronald R. Breaker

    Yale University, United States

    16 publications · 1.7K citations

    16

    h-index

  2. PC
    Philip C. Bevilacqua

    Pennsylvania State University, United States

    15 publications · 1.2K citations

    15

    h-index

  3. MD
    Michael D. Been

    Duke Medical Center, United States

    13 publications · 988 citations

    13

    h-index

  4. AL
    Andrej Lupták

    University of California, Irvine, United States

    10 publications · 895 citations

    10

    h-index

  5. AT
    Anne T. Perrotta

    Duke University Hospital, United States

    9 publications · 766 citations

    9

    h-index

1–5 of 764

Institutions

297

  1. Yale University

    New Haven, United States

    24 h-index

    82 publications

    8.8K citations

  2. Howard Hughes Medical Institute

    Chevy Chase, United States

    23 h-index

    65 publications

    7.5K citations

  3. Pennsylvania State University

    State College, United States

    15 h-index

    49 publications

    3.4K citations

  4. Duke University Hospital

    Durham, United States

    13 h-index

    26 publications

    2.2K citations

  5. Duke Medical Center

    Durham, United States

    13 h-index

    27 publications

    2.3K citations

  6. Centre National de la Recherche Scientifique

    Paris, France

    10 h-index

    28 publications

    542 citations

  7. Instituto de Biología Molecular y Celular de Plantas

    Valencia, Spain

    9 h-index

    18 publications

    1.5K citations

  8. University of California, Irvine

    Irvine, United States

    9 h-index

    27 publications

    1.6K citations

1–8 of 297

Venues

  1. Nucleic Acids Research

    54 publications · 2.1K citations

    29

    h-index

  2. Biochemistry

    29 publications · 1.9K citations

    24

    h-index

  3. Proceedings of the National Academy of Sciences

    PNAS · 20 publications · 1.8K citations

    19

    h-index

  4. RNA

    26 publications · 1.6K citations

    19

    h-index

  5. Journal of the American Chemical Society

    JACS · 10 publications · 777 citations

    10

    h-index

1–5