Concepedia

Sedative Tolerance

Sedative Tolerance is a pharmacological phenomenon characterized by a diminished response to sedative drugs over time, necessitating higher doses to achieve the same therapeutic or physiological effect due to adaptive changes in the central nervous system.

42

Publications

1.7K

Citations

120

Authors

65

Institutions

Publications per year

2017–2026

0

Parents

Publications

42

Requirement of α<sub>5</sub>-GABA<sub>A</sub>Receptors for the Development of Tolerance to the Sedative Action of Diazepam in Mice

Carolien van Rijnsoever, Marcus Täuber, M. Choulli et al. · Journal of Neuroscience · 2004 · 143 citations · Full text

, , +17

Contingent tolerance to the anorexigenic effects of amphetamine

Peter L. Carlton, David L. Wolgin · Physiology & Behavior · 1971 · 125 citations

, , +14

Rapid development of tolerance to the sedative effects of lorazepam and triazolam in rats

Sandra E. File · Psychopharmacology · 1981 · 117 citations

, , +11

Possible Mechanism of Tolerance to Narcotic Drugs

Julius Axelrod · Science · 1956 · 112 citations

, , +17

Influence of dosing regimen on alprazolam and metabolite serum concentrations and tolerance to sedative and psychomotor effects

Randall B. Smith, Patricia D. Kroboth · Psychopharmacology · 1987 · 76 citations

, , +12

1–5 of 42

Authors

120

  1. SE
    Sandra E. File

    University of London, United Kingdom

    7 publications · 412 citations

    7

    h-index

  2. CF
    Cathy Fernandes

    King's College London, United Kingdom

    3 publications · 155 citations

    3

    h-index

  3. ME
    Mark E. Bouton

    University of Vermont, United States

    2 publications · 79 citations

    2

    h-index

  4. DA
    David A. King

    University of Cambridge, United Kingdom

    2 publications · 79 citations

    2

    h-index

  5. SM
    Steve M. Auden

    University of Louisville, United States

    2 publications · 79 citations

    2

    h-index

1–5 of 120

Institutions

65

  1. Guy's Hospital

    London, United Kingdom

    3 h-index

    4 publications

    184 citations

  2. University of London

    London, United Kingdom

    3 h-index

    4 publications

    255 citations

  3. University of Washington

    Seattle, United States

    2 h-index

    3 publications

    67 citations

  4. Duke Medical Center

    Durham, United States

    1 h-index

    4 publications

    224 citations

  5. University of Wisconsin–Milwaukee

    Milwaukee, United States

    1 h-index

    1 publications

    46 citations

  6. Florida Atlantic University

    Boca Raton, United States

    1 h-index

    2 publications

    32 citations

  7. Tufts Medical Center

    Boston, United States

    1 h-index

    1 publications

    46 citations

  8. Washington State University

    Pullman, United States

    1 h-index

    3 publications

    33 citations

1–8 of 65

Venues

  1. Psychopharmacology

    9 publications · 443 citations

    9

    h-index

  2. Pharmacology Biochemistry and Behavior

    6 publications · 189 citations

    6

    h-index

  3. European Journal of Pharmacology

    EJP · 3 publications · 76 citations

    3

    h-index

  4. Journal of Pharmacy and Pharmacology

    JPP · 2 publications · 60 citations

    2

    h-index

  5. Physiology & Behavior

    2 publications · 142 citations

    2

    h-index

1–5