Concepedia

Scale-down Model Validation

Scale-Down Model Validation is a methodological framework in process engineering that enables the verification of large-scale bioprocess performance through experimentally tractable, miniaturized systems designed to accurately replicate critical process parameters and variability of the full-scale operation.

17

Publications

843

Citations

71

Authors

25

Institutions

Publications per year

2017–2026

6

Parents

Publications

17

Advanced microscale bioreactor system: a representative scale-down model for bench-top bioreactors

Wei-Ting Hsu, Rigzen P. S. Aulakh, Donald L. Traul et al. · Cytotechnology · 2012 · 140 citations · Full text

, , +15

An industrial perspective on bioreactor scale‐down: What we can learn from combined large‐scale bioprocess and model fluid studies

Henk Noorman · Biotechnology Journal · 2011 · 124 citations

, , +15

A Systematic Approach for Scale-Down Model Development and Characterization of Commercial Cell Culture Processes

Feng Li, Y. Hashimura, Ronald Pendleton et al. · Biotechnology Progress · 2006 · 111 citations

, , +17

Development of a scale down cell culture model using multivariate analysis as a qualification tool

Valerie Liu Tsang, Angela X. Wang, Helena Yusuf‐Makagiansar et al. · Biotechnology Progress · 2013 · 63 citations

, , +13

From industrial fermentor to CFD-guided downscaling: what have we learned?

Cees Haringa, R.F. Mudde, Henk Noorman · Biochemical Engineering Journal · 2018 · 62 citations · Full text

, , +9

1–5 of 17

Authors

71

  1. HN
    Henk Noorman

    DSM (Netherlands), Netherlands

    2 publications · 186 citations

    2

    h-index

  2. MS
    Matthieu Stettler

    Merck Serono S.A. (Switzerland), Switzerland

    1 publications · 21 citations

    1

    h-index

  3. IH
    Inn H. Yuk

    Cell Culture Company (United States), United States

    1 publications · 140 citations

    1

    h-index

  4. BB
    B. Banko

    University of Ljubljana, Slovenia

    1 publications · 34 citations

    1

    h-index

  5. JM
    Jennifer M. Pollard

    Merck & Co., Inc., Rahway, NJ, USA (United States), United States

    1 publications · 48 citations

    1

    h-index

1–5 of 71

Institutions

25

  1. Altimmune (United States)

    Gaithersburg, United States

    2 h-index

    4 publications

    120 citations

  2. DSM (Netherlands)

    Heerlen, Netherlands

    2 h-index

    3 publications

    248 citations

  3. Biochemical Society

    London, United Kingdom

    2 h-index

    5 publications

    101 citations

  4. University College London

    London, United Kingdom

    2 h-index

    5 publications

    101 citations

  5. Biogen (United States)

    Cambridge, United States

    1 h-index

    4 publications

    252 citations

  6. ETH Zurich

    Zurich, Switzerland

    1 h-index

    4 publications

    84 citations

  7. Planetary Science Institute

    Tucson, United States

    1 h-index

    1 publications

    21 citations

  8. Amgen (United States)

    Thousand Oaks, United States

    1 h-index

    6 publications

    666 citations

1–8 of 25

Venues

  1. Biotechnology Progress

    4 publications · 244 citations

    4

    h-index

  2. Biotechnology Journal

    2 publications · 155 citations

    2

    h-index

  3. International Journal of Energy Research

    1 publications · 15 citations

    1

    h-index

  4. Bioprocess Engineering

    1 publications · 13 citations

    1

    h-index

  5. Journal of Biotechnology

    1 publications · 21 citations

    1

    h-index

1–5