Concepedia

Saturable Kinetics

Saturable Kinetics is a pharmacokinetic process characterized by a nonlinear relationship between drug dose and systemic exposure, in which the metabolic or transport mechanisms exhibit a finite capacity that becomes saturated at higher drug concentrations, leading to disproportionate increases in exposure with dose escalation.

118

Publications

5.9K

Citations

409

Authors

156

Institutions

Publications per year

2017–2026

5

Variants

Nonlinear Kinetics

Parents

Publications

118

Human interleukin (IL) 1 alpha, murine IL-1 alpha and murine IL-1 beta are transported from blood to brain in the mouse by a shared saturable mechanism.

William A. Banks, Luis A. Ortiz, Scott R. Plotkin et al. · Journal of Pharmacology and Experimental Therapeutics · 1991 · 472 citations

, , +12

Silicon Uptake in Diatoms Revisited: A Model for Saturable and Nonsaturable Uptake Kinetics and the Role of Silicon Transporters

Kimberlee Thamatrakoln, Mark Hildebrand · PLANT PHYSIOLOGY · 2007 · 222 citations · Full text

, , +16

Transport of celiprolol across human intestinal epithelial (Caco‐2) cells: mediation of secretion by multiple transporters including P‐glycoprotein

Johan Karlsson, Shiu‐Ming Kuo, John A. Ziemniak et al. · British Journal of Pharmacology · 1993 · 180 citations · Full text

, , +17

Stable Association of Presenilin Derivatives and Absence of Presenilin Interactions with APP

Gopal Thinakaran, Jean B. Regard, Christopher M. L. S. Bouton et al. · Neurobiology of Disease · 1998 · 176 citations · Full text

, , +17

BindingDB Entry 50042069: Methotrexate is excreted into the bile by canalicular multispecific organic anion transporter in rats.

PubMed · 2013 · 172 citations · Full text

, , +17

1–5 of 118

Authors

409

  1. UL
    Umberto Laforenza

    University of Pavia, Italy

    4 publications · 324 citations

    4

    h-index

  2. BV
    Berislav V. Zloković

    University of Southern California, United States

    4 publications · 213 citations

    4

    h-index

  3. HD
    Hugh Davson

    University College London, United Kingdom

    3 publications · 147 citations

    3

    h-index

  4. PS
    Patrı́cio Soares-da-Silva

    Bial (Portugal), Portugal

    3 publications · 110 citations

    3

    h-index

  5. AD
    Antonio Danieli

    University of Salento, Italy

    2 publications · 54 citations

    2

    h-index

1–5 of 409

Institutions

156

  1. Yale University

    New Haven, United States

    5 h-index

    15 publications

    397 citations

  2. University of Pavia

    Pavia, Italy

    5 h-index

    15 publications

    861 citations

  3. University of California, San Francisco

    San Francisco, United States

    3 h-index

    6 publications

    302 citations

  4. Harvard University

    Cambridge, United States

    3 h-index

    5 publications

    301 citations

  5. Rensselaer Polytechnic Institute

    Troy, United States

    2 h-index

    5 publications

    73 citations

  6. Instituto Português de Oncologia Francisco Gentil

    Lisbon, Portugal

    2 h-index

    5 publications

    243 citations

  7. Technical University of Munich

    Munich, Germany

    2 h-index

    5 publications

    139 citations

  8. University of Calgary

    Calgary, Canada

    2 h-index

    8 publications

    192 citations

1–8 of 156

Venues

  1. Journal of Biological Chemistry

    JBC · 7 publications · 397 citations

    7

    h-index

  2. Journal of Neurochemistry

    JNC · 5 publications · 293 citations

    5

    h-index

  3. PubMed

    Repository · 5 publications · 246 citations

    5

    h-index

  4. The Journal of Physiology

    5 publications · 169 citations

    5

    h-index

  5. 4

    h-index

1–5