Concepedia

Route-specific Toxicity

Route-Specific Toxicity is a toxicological construct that denotes the phenomenon whereby the adverse biological effects of a substance vary depending on the route of exposure, thereby distinguishing it from generalized toxicity assessments that do not account for exposure pathway differences.

5

Publications

134

Citations

27

Authors

12

Institutions

Publications per year

2017–2026

1

Parents

Publications

5

Exploring Route-Specific Pharmacokinetics of PFAS in Mice by Coupling <i>in Vivo</i> Tests and Physiologically Based Toxicokinetic Models

Yumin Zhu, Xiaoyu Pan, Yibo Jia et al. · Environmental Health Perspectives · 2023 · 42 citations · Full text

, , +16

Methods for Route-To-Route Extrapolation of Dose

William E. Pepelko, James Withey · Toxicology and Industrial Health · 1985 · 37 citations

, , +15

Can acute dermal systemic toxicity tests be replaced with oral tests? A comparison of route-specific systemic toxicity and hazard classifications under the Globally Harmonized System of Classification and Labelling of Chemicals (GHS)

Nigel P. Moore, David J. Andrew, Donald L. Bjerke et al. · Regulatory Toxicology and Pharmacology · 2013 · 28 citations

, , +13

Evaluation of route-to-route extrapolation factors based on assessment of repeated dose toxicity studies compiled in the database RepDose®

Katrin Schröder, Sylvia E. Escher, Simone Hoffmann-Dörr et al. · Toxicology Letters · 2016 · 17 citations

, , +11

Application of a skin and liver Chip2 microphysiological model to investigate the route‐dependent toxicokinetics and toxicodynamics of consumer‐relevant doses of genistein

Thi‐Phuong Tao, Katrin Brandmair, Silke Gerlach et al. · Journal of Applied Toxicology · 2023 · 12 citations · Full text

, , +13

1–5 of 5

Authors

27

  1. DL
    Donald L. Bjerke

    Procter & Gamble (United States), United States

    1 publications · 28 citations

    1

    h-index

  2. TH
    Thomas Holmes

    Lovelace Respiratory Research Institute, United States

    1 publications · 28 citations

    1

    h-index

  3. JD
    Jiaqi Ding

    Huazhong University of Science and Technology, China

    1 publications · 42 citations

    1

    h-index

  4. XS
    Xiaohua Song

    Nankai University, China

    1 publications · 42 citations

    1

    h-index

  5. JF
    Jianfeng Feng

    Nankai University, China

    1 publications · 42 citations

    1

    h-index

1–5 of 27

Institutions

12

  1. Procter & Gamble (United States)

    Cincinnati, United States

    1 h-index

    1 publications

    28 citations

  2. Helmholtz Centre for Environmental Research

    Leipzig, Germany

    1 h-index

    1 publications

    17 citations

  3. Health Canada

    Ottawa, Canada

    1 h-index

    1 publications

    37 citations

  4. Fraunhofer Institute for Toxicology and Experimental Medicine

    Hanover, Germany

    1 h-index

    4 publications

    68 citations

  5. Nankai University

    Tianjin, China

    1 h-index

    8 publications

    336 citations

  6. Environmental Protection Agency

    Washington, United States

    1 h-index

    1 publications

    37 citations

  7. Covance (United Kingdom)

    Harrogate, United Kingdom

    1 h-index

    1 publications

    28 citations

  8. Covance (United States)

    Princeton, United States

    1 h-index

    1 publications

    28 citations

1–8 of 12

Venues

  1. Toxicology Letters

    1 publications · 17 citations

    1

    h-index

  2. Environmental Health Perspectives

    EHP · 1 publications · 42 citations

    1

    h-index

  3. Toxicology and Industrial Health

    1 publications · 37 citations

    1

    h-index

  4. Regulatory Toxicology and Pharmacology

    RTP · 1 publications · 28 citations

    1

    h-index

  5. Journal of the American College of Toxicology

    1 publications · 10 citations

    1

    h-index

1–5