Concepedia

Ribozymes

Ribozyme is a catalytic RNA molecule that, unlike typical ribonucleic acids, possesses inherent enzymatic activity enabling it to catalyze specific biochemical reactions, most commonly the cleavage or ligation of phosphodiester bonds in RNA substrates.

2.1K

Publications

127.5K

Citations

4.4K

Authors

1K

Institutions

Publications per year

2017–2026

184

Variants

Ribozyme

Parents

Publications

2.1K

The RNA moiety of ribonuclease P is the catalytic subunit of the enzyme

Cecilia Guerrier-Takada, Katheleen Gardiner, Norman R. Pace et al. · Cell · 1983 · 2.7K citations

, , +14

Crystal Structure of a Group I Ribozyme Domain: Principles of RNA Packing

J.H.D. Cate, Anne R. Gooding, Elaine R. Podell et al. · Science · 1996 · 1.2K citations

, , +17

Three-dimensional structure of a hammerhead ribozyme

Heinz W. Pley, Kevin Flaherty, David McKay · Nature · 1994 · 957 citations

, , +14

Control of gene expression by a natural metabolite-responsive ribozyme

Wade C. Winkler, Ali Nahvi, Adam Roth et al. · Nature · 2004 · 954 citations

, , +12

A Single-Molecule Study of RNA Catalysis and Folding

Xiaowei Zhuang, Laura Bartley, Hazen P. Babcock et al. · Science · 2000 · 738 citations

, , +17

1–5 of 2.1K

Authors

4.4K

  1. TR
    Thomas R. Cech

    Howard Hughes Medical Institute, United States

    48 publications · 7.6K citations

    40

    h-index

  2. GF
    Gerald F. Joyce

    Scripps Research Institute, United States

    42 publications · 3.9K citations

    31

    h-index

  3. DH
    Daniel Herschlag

    Stanford University, United States

    41 publications · 4.3K citations

    31

    h-index

  4. RR
    Ronald R. Breaker

    Yale University, United States

    34 publications · 5.6K citations

    28

    h-index

  5. DM
    David M.J. Lilley

    University of Dundee, United Kingdom

    36 publications · 2.2K citations

    28

    h-index

1–5 of 4.4K

Institutions

1K

  1. Howard Hughes Medical Institute

    Chevy Chase, United States

    63 h-index

    270 publications

    35.2K citations

  2. Yale University

    New Haven, United States

    56 h-index

    228 publications

    40.6K citations

  3. University of Colorado Boulder

    Boulder, United States

    51 h-index

    183 publications

    27.4K citations

  4. Scripps Research Institute

    San Diego, United States

    36 h-index

    136 publications

    8.5K citations

  5. Stanford University

    Stanford, United States

    34 h-index

    160 publications

    19.5K citations

  6. Pennsylvania State University

    State College, United States

    30 h-index

    117 publications

    9.3K citations

  7. University of Dundee

    Dundee, United Kingdom

    30 h-index

    95 publications

    7K citations

  8. University of Vermont

    Burlington, United States

    29 h-index

    105 publications

    8.8K citations

1–8 of 1K

Venues

  1. Proceedings of the National Academy of Sciences

    PNAS · 106 publications · 9.4K citations

    58

    h-index

  2. Nucleic Acids Research

    225 publications · 11.6K citations

    57

    h-index

  3. Biochemistry

    157 publications · 9.2K citations

    56

    h-index

  4. Journal of the American Chemical Society

    JACS · 97 publications · 6.3K citations

    47

    h-index

  5. Journal of Molecular Biology

    JMB · 82 publications · 5.1K citations

    45

    h-index

1–5