Concepedia

Ribosomal Scanning

Ribosomal Scanning is a molecular mechanism in eukaryotic translation initiation whereby the small ribosomal subunit, after binding to the 5' cap of an mRNA, progressively examines the nucleotide sequence in the 5' to 3' direction to locate the correct start codon, typically the first AUG in optimal context, thereby determining the reading frame for protein synthesis.

81

Publications

6.3K

Citations

330

Authors

127

Institutions

Publications per year

2017–2026

14

Parents

Publications

81

The roles of individual eukaryotic translation initiation factors in ribosomal scanning and initiation codon selection

Tatyana V. Pestova, Victoria Kolupaeva · Genes & Development · 2002 · 571 citations · Full text

, , +17

Translation of Vascular Endothelial Growth Factor mRNA by Internal Ribosome Entry: Implications for Translation under Hypoxia

Ilan Stein, Ahuva Itin, Paz Einat et al. · Molecular and Cellular Biology · 1998 · 498 citations · Full text

, , +17

Mutations at a Zn(II) finger motif in the yeast elF-2β gene alter ribosomal start-site selection during the scanning process

Thomas F. Donahue, A. Mark Cigan, E K Pabich et al. · Cell · 1988 · 282 citations

, , +12

GTP hydrolysis controls stringent selection of the AUG start codon during translation initiation in<i>Saccharomyces cerevisiae</i>

Han-kuei Huang, Heejeong Yoon, Ernest M. Hannig et al. · Genes & Development · 1997 · 210 citations · Full text

, , +17

tRNA <sub>i</sub> <sup>met</sup> Functions in Directing the Scanning Ribosome to the Start Site of Translation

A. Mark Cigan, Lan Feng, Thomas F. Donahue · Science · 1988 · 206 citations

, , +15

1–5 of 81

Authors

330

  1. TF
    Thomas F. Donahue

    Indiana University Bloomington, United States

    5 publications · 922 citations

    5

    h-index

  2. AM
    A. Mark Cigan

    Pioneer Hi-Bred, United States

    4 publications · 712 citations

    4

    h-index

  3. EK
    E K Pabich

    Northwestern University, United States

    3 publications · 506 citations

    3

    h-index

  4. IN
    Ivan N. Shatsky

    Lomonosov Moscow State University, Russia

    3 publications · 148 citations

    3

    h-index

  5. VP
    Vera P. Pisareva

    SUNY Downstate Health Sciences University, United States

    3 publications · 143 citations

    3

    h-index

1–5 of 330

Institutions

127

  1. National Institutes of Health

    Bethesda, United States

    5 h-index

    17 publications

    1.4K citations

  2. Centre National de la Recherche Scientifique

    Paris, France

    5 h-index

    15 publications

    1.1K citations

  3. Inserm

    Paris, France

    4 h-index

    16 publications

    1.2K citations

  4. SUNY Downstate Health Sciences University

    Brooklyn, United States

    4 h-index

    10 publications

    1.6K citations

  5. Institute of Protein Research

    Pushchino, Russia

    4 h-index

    9 publications

    565 citations

  6. Northwestern University

    Evanston, United States

    3 h-index

    10 publications

    2.2K citations

  7. University of Manchester

    Manchester, United Kingdom

    3 h-index

    7 publications

    639 citations

  8. Lomonosov Moscow State University

    Moscow, Russia

    3 h-index

    15 publications

    766 citations

1–8 of 127

Venues

  1. Nucleic Acids Research

    12 publications · 585 citations

    12

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  2. Journal of Biological Chemistry

    JBC · 9 publications · 705 citations

    9

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  3. Molecular and Cellular Biology

    MCB · 7 publications · 947 citations

    7

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  4. Journal of Virology

    JVI · 6 publications · 385 citations

    6

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  5. The EMBO Journal

    4 publications · 326 citations

    4

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