Concepedia

Replication-driven Mutagenesis

Replication-Driven Mutagenesis is a molecular genetic mechanism in virology wherein erroneous viral genome replication, facilitated by error-prone polymerases and lack of proofreading, generates genetic diversity through the accumulation of mutations during successive rounds of viral amplification.

26

Publications

1.7K

Citations

79

Authors

55

Institutions

Publications per year

2017–2026

1

Parents

Publications

26

Selection for Robustness in Mutagenized RNA Viruses

Rafael Sanjuán, José M. Cuevas, Victoria Furió et al. · PLoS Genetics · 2007 · 342 citations · Full text

, , +12

Local mutagenesis: a method for generating viral mutants with base substitutions in preselected regions of the viral genome.

David Shortle, Daniel Nathans · Proceedings of the National Academy of Sciences · 1978 · 284 citations · Full text

, , +14

Favipiravir elicits antiviral mutagenesis during virus replication in vivo

Armando Arias, Lucy Thorne, Ian Goodfellow · eLife · 2014 · 158 citations · Full text

, , +17

Mutagenesis versus Inhibition in the Efficiency of Extinction of Foot-and-Mouth Disease Virus

Nonia Pariente, Antero Airaksinen, Esteban Domingo · Journal of Virology · 2003 · 101 citations · Full text

, , +17

100 years of virology: from vitalism via molecular biology to genetic engineering

Trends in Microbiology · 2000 · 97 citations

, , +14

1–5 of 26

Authors

79

  1. ED
    Esteban Domingo

    Centro de Biología Molecular Severo Ochoa, Spain

    4 publications · 253 citations

    4

    h-index

  2. CP
    Celia Perales

    Universidad Autónoma de Madrid, Spain

    3 publications · 152 citations

    3

    h-index

  3. RS
    Rafael Sanjuán

    Universitat de València, Spain

    2 publications · 352 citations

    2

    h-index

  4. JM
    José M. Cuevas

    Universitat de València, Spain

    2 publications · 352 citations

    2

    h-index

  5. EC
    Edward C. Holmes

    The University of Sydney, Australia

    2 publications · 352 citations

    2

    h-index

1–5 of 79

Institutions

55

  1. Universidad Autónoma de Madrid

    Madrid, Spain

    4 h-index

    12 publications

    823 citations

  2. Centro de Biología Molecular Severo Ochoa

    Madrid, Spain

    4 h-index

    12 publications

    823 citations

  3. Consejo Superior de Investigaciones Científicas

    Madrid, Spain

    3 h-index

    6 publications

    482 citations

  4. Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas

    Madrid, Spain

    2 h-index

    4 publications

    114 citations

  5. University of New Mexico

    Albuquerque, United States

    1 h-index

    1 publications

    23 citations

  6. Centro de Astrobiología

    Torrejón de Ardoz, Spain

    1 h-index

    2 publications

    52 citations

  7. University of Utah

    Salt Lake City, United States

    1 h-index

    2 publications

    186 citations

  8. Addenbrooke's Hospital

    Cambridge, United Kingdom

    1 h-index

    3 publications

    474 citations

1–8 of 55

Venues

  1. Virology

    6 publications · 202 citations

    6

    h-index

  2. Journal of Virology

    JVI · 3 publications · 171 citations

    3

    h-index

  3. Proceedings of the National Academy of Sciences

    PNAS · 2 publications · 311 citations

    2

    h-index

  4. PLoS Genetics

    2 publications · 352 citations

    2

    h-index

  5. Journal of Molecular Biology

    JMB · 2 publications · 121 citations

    2

    h-index

1–5